Evidence map›Paper›PMID 35672823›Full record

ArticleJournal of translational medicine2022

Perspectives in Immunotherapy: meeting report from the Immunotherapy Bridge, December 1st-2nd, 2021.

Paolo A Ascierto, Antonio Avallone, Nina Bhardwaj, Carlo Bifulco, Sergio Bracarda, Joshua D Brody, Luigi Buonaguro, Sandra Demaria, Leisha A Emens, Robert L Ferris and 13 more

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 18 institutions in 6 countries.

Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
Antonio AvalloneExperimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Nina BhardwajTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carlo BifulcoProvidence Genomics and Earle A. Chiles Research Institute, Portland, OR, USA.
Sergio BracardaMedical and Translational Oncology Unit, Department of Oncology, Azienda Ospedaliera Santa Maria, Terni, Italy.
Joshua D BrodyDepartment of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Luigi BuonaguroDepartment of Experimental Oncology, Innovative Immunological Models Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medical College; Sandra and Edward Meyer Cancer Center; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Leisha A EmensMagee Women's Hospital/UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Robert L FerrisUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Jérôme GalonINSERM, Laboratory of Integrative Cancer Immunology/Equipe Labellisée Ligue Contre Le Cancer/Centre de Recherche Des Cordeliers, Sorbonne Université, Université Paris Cité, Marseille, France.
Samir N KhleifThe Loop Immuno Oncology Laboratory, Georgetown University Medical School, Washington, DC, USA.
Christopher A KlebanoffHuman Oncology and Pathogenesis Program, Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center (MSKCC)/Center for Cell Engineering, MSKCC/Parker Institute for Cancer Immunotherapy/Weill Cornell Medical College, New York, NY, USA.
Tamara LaskowskiHead of New Therapeutic Products - Personalized Medicine, Lonza Global, Houston, TX, USA.
Ignacio MeleroDepartment of Immunology and Immunotherapy, Clinica Universidad de Navarra and CIBERONC, Pamplona, Spain.
Chrystal M PaulosWinship Cancer Institute at Emory University, Atlanta, GA, USA.
Sandro PignataDepartment of Urology and Gynecology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Marco RuellaCenter for Cellular Immunotherapies and Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Inge Marie SvaneNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Janis M TaubeDepartment of Dermatology, Johns Hopkins University SOM, Baltimore, MD, USA.
Bernard A FoxEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Cancer Institute, Portland, OR, USA.
Patrick HwuMoffitt Cancer Center, Tampa, FL, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITIcahn School of Medicine at Mount Sinai · USProvidence Portland Medical Center · USAzienda Ospedaliera S.Maria · ITClinica Universidad de Navarra · ESCopenhagen University Hospital · DKCornell University · USEmory University · USGeorgetown University · USInserm · FRJohns Hopkins University · USLonza (United States) · USMagee-Womens Hospital · USMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USRoswell Park Comprehensive Cancer Center · USUniversity of Pennsylvania · USUPMC Hillman Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Project 3: Combinatorial and gene-editing approaches to enhance the efficacy of CAR T cell therapy of multiple myeloma.P01CA214278 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Joseph Anthony Fraietta · 2017 to 2026
$26.8M
MODULATION OF CD5 SIGNALING TO ENHANCE ADOPTIVE T-CELL THERAPIES FOR CANCERR37CA262362 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Marco Ruella · 2022 to 2026
$2.6M
Resistance To Targeted Immunotherapies:CART19 as a ParadigmR00CA212302 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUELLA, MARCO · 2018 to 2020
$608k
Resistance To Targeted Immunotherapies:CART19 as a ParadigmK99CA212302 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUELLA, MARCO · 2017 to 2018
$348k
NCI NIH HHS K99 CA212302NCI NIH HHS P01 CA214278NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA212302
6 · The paper itself

Abstract

Over the past decade, immunotherapy has become an increasingly fundamental modality in the treatment of cancer. The positive impact of immune checkpoint inhibition, especially anti-programmed death (PD)-1/PD-ligand (L)1 blockade, in patients with different cancers has focused attention on the potential for other immunotherapeutic approaches. These include inhibitors of additional immune checkpoints, adoptive cell transfer (ACT), and therapeutic vaccines. Patients with advanced cancers who previously had limited treatment options available may now benefit from immunotherapies that can offer durable responses and improved survival outcomes. However, despite this, a significant proportion of patients fail to respond to immunotherapy, especially those with less immunoresponsive cancer types, and there remains a need for new treatment strategies.The virtual Immunotherapy Bridge (December 1st-2nd, 2021), organized by the Fondazione Melanoma Onlus, Naples, Italy in collaboration with the Society for Immunotherapy of Cancer addressed several areas of current research in immunotherapy, including lessons learned from cell therapies, drivers of immune response, and trends in immunotherapy across different cancers, and these are summarised here.

Indexed as

Biomarkers, TumorMelanomaHumansImmunologic FactorsImmunotherapyItalyBiomarkers, TumorImmunologic FactorsBiomarkersCheckpoint inhibitorsCombination therapyImmunotherapyTumor microenvironmentVaccine

Identifiers

PMID35672823
PMCPMC9172186
OpenAlexW4281677392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.