Evidence map›Paper›PMID 35672805›Full record

ArticleJournal of animal science and biotechnology2022

Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets.

Min Song, Fenglin Zhang, Yiming Fu, Xin Yi, Shengchun Feng, Zhichang Liu, Dun Deng, Qiang Yang, Miao Yu, Canjun Zhu and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Min SongGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Fenglin ZhangGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Yiming FuGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Xin YiGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Shengchun FengGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Zhichang LiuInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Guangzhou, 510640, P. R. China.
Dun DengInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Guangzhou, 510640, P. R. China.
Qiang YangGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Miao YuInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Guangzhou, 510640, P. R. China.
Canjun ZhuGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Xiaotong ZhuGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Lina WangGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Ping GaoGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Gang ShuGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China.
Xianyong MaInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Guangzhou, 510640, P. R. China.
Qingyan JiangGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China. qyjiang@scau.edu.cn.
Songbo WangGuangdong Provincial Key Laboratory of Animal Nutrition Control, ALLTECH-SCAU Animal Nutrition Control Research Alliance, and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P. R. China. songbowang@scau.edu.cn.ORCID http://orcid.org/0000-0001-9190-9401
South China Agricultural University · CNGuangdong Academy of Agricultural Sciences · CNKey Laboratory of Guangdong Province · CN

Funding

Guangdong Key Areas Research and Development Project 2019B020218001Innovative Research Group Project of the National Natural Science Foundation of China 31790411Innovative Research Group Project of the National Natural Science Foundation of China 31802103Innovative Research Group Project of the National Natural Science Foundation of China 31972636,31672508National Key Research and Development Program of China 2017YFD0500501Provincial Agricultural Science and Technology Innovation Promotion and Agricultural Resources and Ecological Environmental Protection Construction Project 2021KJ266
6 · The paper itself

Abstract

backgroundTauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases. Meanwhile, TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in mice. However, the effect of TUDCA on the intestinal barrier of weaned piglets remains largely unclear.

methodsThe weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying mechanisms. In vivo, 72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight, and piglets were fed the basal diet with 0 (control, CON) and 200 mg/kg TUDCA for 30 d, respectively. Three female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were collected. In vitro, IPEC-J2 cells were subjected to 100 μmol/L TUDCA to explore the possible underlying mechanisms.

resultsOur results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets, possibly attributing to the TUDCA-enhanced intestinal barrier function and immunity. In addition, TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria, which might contribute to the improved intestinal barrier function. Furthermore, the in-vitro results showed that TUDCA improved the E. coli-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5 (TGR5) protein expression. However, knockdown of TGR5 and inhibition of myosin light chain kinase (MLCK) pathway abolished the TUDCA-improved epithelial barrier impairment in E. coli-treated IPEC-J2 cells, indicating the involvement of TGR5-MLCK in this process.

conclusionsThese findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets, suggesting the potential application of TUDCA in improving gut health in piglet production.

Indexed as

Gut bacteriaIntestinal barrier functionSerum metabolitesTauroursodeoxycholic acid (TUDCA)TGR5-MLCK pathwayWeaned piglets

Identifiers

PMID35672805
PMCPMC9175448
OpenAlexW4281725834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.