Trial reportBMC musculoskeletal disorders2022
Exploratory insights into novel prehabilitative neuromuscular exercise-conditioning in total knee arthroplasty.
Trial report in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03113032 (Novel Pre-Surgery Exercise-Conditioning in Patients Waiting for Total Knee Arthroplasty), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Pre-Surgery Exercise-Conditioning in Patients Waiting for Total Knee Arthroplasty (TKA)
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta-Analysis of Randomized Controlled Trials.Orthopaedic surgery · 2025Pooled it
- Prehabilitation for Patients Undergoing Orthopedic Surgery: A Systematic Review and Meta-analysis.JAMA network open · 2023Pooled it
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Outcome measures in prehabilitation interventions for total hip and knee arthroplasty: A scoping review.Clinical rehabilitation · 2026Article
- Effects of Resistance Training on Pain, Muscle Strength, and Function in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Prehabilitation for Patients Undergoing Elective Foot and Ankle Surgery: A Contemporary Review.Foot & ankle orthopaedics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContemporary strategies for prehabilitation and rehabilitation associated with total knee arthroplasty (TKA) surgery have focused on improving joint range-of-motion and function with less emphasis on neuromuscular performance beneficially affecting joint stability. Furthermore, prehabilitation protocols have been found to be too long and generic-in-effect to be considered suitable for routine clinical practice.
methodsA pragmatic exploratory controlled trial was designed to investigate the efficacy of a novel, acute prehabilitative neuromuscular exercise-conditioning (APNEC) in patients electing TKA. Adults electing unilateral TKA were assessed and randomly allocated to exercise-conditioning (APNEC, n = 15) and usual care (Control, n = 14) from a specialised orthopaedic hospital, in the United Kingdom. APNEC prescribed nine stressful exercise-conditioning sessions for the knee extensors of the surgery leg, accrued over one week (3 sessions·week
resultsGroup mean ipsilateral knee extensor muscular activation capacity (EMD
conclusionsThe exploratory APNEC protocol elicited significant and clinically-relevant improvement and its retention in neuromuscular performance in patients awaiting TKA.
trial registration(date and number): clinicaltrial.gov: NCT03113032 (4/04/2017) and ISRCTN75779521 (3/5/2017).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.