ArticleBMC genomics2022
Gene network analysis reveals candidate genes related with the hair follicle development in sheep.
Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Whole-Genome Resequencing Reveals Selection Signatures Associated With Lambskin Patterns in Hu Sheep.Animal genetics · 2026Article
- Transcriptome and proteome combined analysis of wool fiber diameter regulation mechanism.Animal bioscience · 2026Article
- Landscape genomics analysis reveals the genetic basis underlying cashmere goats and dairy goats adaptation to frigid environments.Stress biology · 2025Article
- Article
- Identification of lncRNAs involved in the hair follicle cycle transition of cashmere goats in response to photoperiod change.BMC genomics · 2025Article
- Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats.Frontiers in veterinary science · 2025Review
- Whole-Genome Resequencing to Identify Selection Signatures Associated with High Fertility in Lüliang Black Goat.Animals : an open access journal from MDPI · 2024Article
- Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert.BMC genomics · 2024Article
- MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development.Cells · 2024Article
- Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep.Journal of advanced research · 2024Article
- Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness.Frontiers in genetics · 2024Article
- Whole genome sequencing identified genomic diversity and candidated genes associated with economic traits in Northeasern Merino in China.Frontiers in genetics · 2024Article
- Unlocking the genetic secrets of Dorper sheep: insights into wool shedding and hair follicle development.Frontiers in veterinary science · 2024Article
- Association analysis for SNPs ofAnimal biotechnology · 2023Article
- Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts.Development (Cambridge, England) · 2023Article
- Proteome Analysis of Alpine Merino Sheep Skin Reveals New Insights into the Mechanisms Involved in Regulating Wool Fiber Diameter.International journal of molecular sciences · 2023Article
- Review
- Construction of a neural network diagnostic model for renal fibrosis and investigation of immune infiltration characteristics.Frontiers in immunology · 2023Article
- Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development.BMC genomics · 2022Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMerino sheep are the most famous fine wool sheep in the world. They have high wool production and excellent wool quality and have attracted worldwide attention. The fleece of the Merino sheep is composed predominantly of wool fibers grown from secondary wool follicles. Therefore, it is necessary to study the development of hair follicles to understand the mechanism of wool production. The hair follicle is a complex biological system involved in a dynamic process governed by gene regulation. The hair follicle development process is very complex and poorly understood. The purpose of our research is to identify candidate genes related to hair follicle development, provide a theoretical molecular breeding basis for the cultivation of fine wool sheep, and provide a reference for the problems of hair loss and alopecia areata that affect human beings.
resultsWe analyzed mRNAs data in skin tissues of 18 Merino sheep at four embryonic days (E65, E85, E105 and E135) and two postnatal days (P7 and P30). G1 to G6 represent hair follicles developmental at six stages (i.e. E65 to P30). We identified 7879 differentially expressed genes (DEGs) and 12623 novel DEGs, revealed different expression patterns of these DEGs at six stages of hair follicle development, and demonstrated their complex interactions. DEGs with stage-specific expression were significantly enriched in epidermal differentiation and development, hair follicle development and hair follicle morphogenesis and were enriched in many pathways related to hair follicle development. The key genes (LAMA5, WNT10A, KRT25, SOSTDC1, ZDHHC21, FZD1, BMP7, LRP4, TGFβ2, TMEM79, SOX10, ITGB4, KRT14, ITGA6, and GLI2) affecting hair follicle morphogenesis were identified by network analysis.
conclusionThis study provides a new reference for the molecular basis of hair follicle development and lays a foundation for further improving sheep hair follicle breeding. Candidate genes related to hair follicular development were found, which provided a theoretical basis for molecular breeding for the culture of fine wool sheep. These results are a valuable resource for biological investigations of fleece evolution in animals.
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