Evidence map›Paper›PMID 35672598›Full record

ArticleObesity surgery2022

GDF15 and Cortisol Response to Meal Tolerance Test in Post-Sleeve Gastrectomy Patients with Weight Regain.

Jenny Pena Dias, Olga Carlson, Michael Schweitzer, Michelle Shardell, Jeanne M Clark, Todd T Brown, Josephine M Egan, Clare J Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jenny Pena DiasDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA. jpenadi1@jhu.edu.ORCID 0000-0002-8171-0543
Olga CarlsonNational Institute of Aging, NIH, Baltimore, MD, USA.
Michael SchweitzerDepartment of Surgery, Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA.
Michelle ShardellDepartment of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, MD, USA.
Jeanne M ClarkDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA.
Todd T BrownDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA.
Josephine M EganNational Institute of Aging, NIH, Baltimore, MD, USA.
Clare J LeeDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA.
Johns Hopkins University · USNational Institute on Aging · USUniversity of Maryland, Baltimore · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
Mentoring in Endocrine and Metabolic Abnormalities in HIV and AgingK24AI120834 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T · 2015 to 2025
$1.8M
Methods to Test Lifestyle, Vaginal Microenvironment, and Genitourinary Symptoms across Menopause TransitionR56AG068673 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI BROTMAN, REBECCA M., SHARDELL, MICHELLE DENISE · 2020 to 2020
$796k
Exploring Mechanisms of Changes in Glucose Homeostasis After Bariatric Surgery: Comparing Vertical Sleeve Gastrectomy and Roux-en-Y Gastric BypassK23DK107921 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LEE, CLARE JUNG EUN · 2016 to 2018
$582k
Epidemiology of the Inverse Comorbidity of Dementia and Cancer: Statistical Methods and Biological MechanismsR03AG070178 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2021 to 2021
$309k
Intramural NIH HHS Z99 AG999999NIAID NIH HHS K24 AI120834NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG048069NIA NIH HHS R03 AG070178NIA NIH HHS R56 AG068673NIDDK NIH HHS K23 DK107921
6 · The paper itself

Abstract

backgroundHormonal factors behind weight regain (WR) after surgical weight loss remain inadequately understood. Growth/differentiation factor 15 (GDF15) has emerged as a potential therapeutic target in obesity treatment. Cortisol, another stress hormone, has also been associated with weight gain at both low and high circulating concentrations. We aimed to compare meal-stimulated GDF15 and cortisol response in adults with and without WR after sleeve gastrectomy (SG). We hypothesized that GDF15 and cortisol response to meal tolerance test (MTT) will be lower in those with versus without WR after SG.

methodsCross-sectional study comprised 21 adults without diabetes, who underwent SG. WR was defined as 100 × (current weight - nadir)/(preoperative weight - nadir) > 10%. GDF15, cortisol, insulin, glucose, and incretins (total glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) circulating concentrations) were measured during MTT (0-240 min) after 3-6 years post-bariatric surgery.

resultsAll participants were 48% White, 85% female, with mean (SD) age: 43(10) years, and BMI: 36.2(7.6) kg/m

conclusionsGDF15 and cortisol responses to MTT were lower in those who regained the weight after SG compared to those who did not, suggesting that dysregulation in GDF15 and cortisol response following bariatric surgery.

Indexed as

HydrocortisoneObesity, MorbidAdultBlood GlucoseCross-Sectional StudiesFemaleGastrectomyGlucoseGrowth Differentiation Factor 15HumansIncretinsInsulinMaleWeight GainBlood GlucoseGDF15 protein, humanGlucoseGrowth Differentiation Factor 15HydrocortisoneIncretinsInsulinBariatric surgeryCortisolGDF15Weight regain

Identifiers

PMID35672598
PMCPMC9972254
OpenAlexW4281782913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.