Evidence map›Paper›PMID 35672584›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation.

Shizu Shinohara, Andrey Bychkov, Jijgee Munkhdelger, Kishio Kuroda, Han-Seung Yoon, Shota Fujimura, Kazuhiro Tabata, Bungo Furusato, Daisuke Niino, Shinpei Morimoto and 20 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Integrating cytology into routine digital pathology workflow: a 5-year journey.Virchows Archiv : an international journal of pathology · 2023
    Article
  5. Article
  6. Optimizing Re-staining Techniques for the Restoration of Faded Hematoxylin and Eosin-stained Histopathology Slides: A Comparative Study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 19 institutions in 1 country.

Shizu ShinoharaDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Andrey BychkovKameda Medical Center, Kamogawa, Japan.
Jijgee MunkhdelgerKameda Medical Center, Kamogawa, Japan.
Kishio KurodaDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Han-Seung YoonDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Shota FujimuraDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Kazuhiro TabataDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Bungo FurusatoDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Daisuke NiinoDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Shinpei MorimotoDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Takashi YaoJuntendo University, Tokyo, Japan.
Tomoo ItohKobe University, Kobe, Japan.
Hajime AoyamaUniversity of Ryukyus, Okinawa, Japan.
Naoko TsuyamaJapanese Foundation for Cancer Research, Tokyo, Japan.
Yoshiki MikamiKumamoto University Hospital, Kumamoto, Japan.
Toshitaka NagaoTokyo Medical University, Tokyo, Japan.
Tohru IkedaTokyo Medical and Dental University, Tokyo, Japan.
Noriyoshi FukushimaJichi Medical University, Shimotsuge, Japan.
Oi HaradaKameda Medical Center, Kamogawa, Japan.
Takako KiyokawaThe Jikei University School of Medicine, Tokyo, Japan.
Naoki YoshimiUniversity of Ryukyus, Okinawa, Japan.
Shinichi AishimaSaga University, Saga, Japan.
Ichiro MaedaKitasato University School of Medicine, Sagamihara, Japan.
Ichiro MoriInternational University of Health and Welfare, Narita, Japan.
Koji YamanegiHyogo College of Medicine, Nishinomiya, Japan.
Koichi TsuneyamaTokushima University Graduate School of Science, Tokushima, Japan.
Ryohei KatohIto Hospital, Tokyo, Japan.
Miki IzumiShowa University, Tokyo, Japan.
Yoshinao OdaKyushu University, Fukuoka, Japan.
Junya FukuokaDepartment of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan. fukuokaj@nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0002-2496-3050
Nagasaki University · JPKameda Medical Center · JPUniversity of the Ryukyus · JPHyogo Medical University · JPInternational University of Health and Welfare · JPIto Hospital · JPJapanese Foundation For Cancer Research · JPJichi Medical University · JPJikei University School of Medicine · JPJuntendo University Hospital · JPKitasato University · JPKobe University · JPKumamoto University Hospital · JPKyushu University · JPSaga University · JPShowa University Hospital · JPTokushima University · JPTokyo Medical and Dental University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consultation by subspecialty experts is the most common mode of rendering diagnosis in challenging cases in pathological practice. Our study aimed to highlight the diagnostic benefits of whole-slide image (WSI)-based remote consultation. We obtained diagnostically challenging cases from two institutions from the years 2010 and 2013, with histological diagnoses that contained keywords "probable," "suggestive," "suspicious," "inconclusive," and "uncertain." A total of 270 cases were selected for remote consultation using WSIs scanned at 40 × . The consultation process consisted of three rounds: the first and second rounds each with 12 subspecialty experts and the third round with six multi-expertise senior pathologists. The first consultation yielded 44% concordance, and a change in diagnosis occurred in 56% of cases. The most frequent change was from inconclusive to definite diagnosis (30%), followed by minor discordance (14%), and major discordance (12%). Out of the 70 cases which reached the second round, 31 cases showed discrepancy between the two consultants. For these 31 cases, a consensus diagnosis was provided by six multi-expertise senior pathologists. Combining all WSI-based consultation rounds, the original inconclusive diagnosis was changed in 140 (52%) out of 266 cases. Among these cases, 80 cases (30%) upgraded the inconclusive diagnosis to a definite diagnosis, and 60 cases (22%) changed the diagnosis with major or minor discordance, accounting for 28 cases (10%) and 32 cases (12%), respectively. We observed significant improvement in the pathological diagnosis of difficult cases by remote consultation using WSIs, which can further assist in patient healthcare. A post-study survey highlighted various benefits of WSI-based consults.

Indexed as

Pathology, SurgicalRemote ConsultationTelepathologyHumansMicroscopyConsultationDigital pathologySecond opinionTelepathologyWhole-slide imaging

Identifiers

PMID35672584
PMCPMC9172976
OpenAlexW4281760176

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.