Evidence map›Paper›PMID 35672539›Full record

ArticleJournal of assisted reproduction and genetics2022

Estradiol to progesterone ratio is not a predictor of oocyte maturity at time of ovulation trigger.

Marisa Berger, Hency Patel, Richard Buyalos, Gary Hubert, Chumin Wang, Mousa Shamonki, Molly Quinn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marisa BergerObstetrics and Gynecology, University of California Los Angeles, Los Angeles, CA, USA. mberger@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-4401-1727
Hency PatelObstetrics and Gynecology, University of California Los Angeles, Los Angeles, CA, USA.
Richard BuyalosFertility and Surgical Associates of California, Thousand Oaks, CA, USA.
Gary HubertFertility and Surgical Associates of California, Thousand Oaks, CA, USA.
Chumin WangFertility and Surgical Associates of California, Thousand Oaks, CA, USA.
Mousa ShamonkiObstetrics and Gynecology, University of California Los Angeles, Los Angeles, CA, USA.
Molly QuinnUniversity of Southern California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity Surgical Associates · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the relationship between progesterone and oocyte maturity rate via estradiol to progesterone ratio (E/P) at the time of ovulatory trigger.

methodsThis is a retrospective cohort study of first autologous IVF cycles from January to December 2018 from a private practice fertility center. Serum estradiol and progesterone levels were measured on the day of ovulatory trigger. E/P was calculated to control for degree of response. Embryos were cultured to the blastocyst stage for trophectoderm biopsy. Preimplantation genetic testing for aneuploidy (PGT-A) was performed using next-generation sequencing (NGS). Oocyte retrieval rate (oocytes retrieved/follicles ≥ 13 mm), maturity rate (MII/oocytes retrieved), and euploid rate (euploid/total biopsied embryos) were calculated. Clinical pregnancy, ongoing pregnancy (> 10 weeks), and live births following frozen embryo transfer (FET) were examined in relation to E/P. Regression analyses were performed to analyze E/P as a categorical value (defined by quartile) on oocyte maturity.

resultsTwo hundred eleven women underwent controlled ovarian hyperstimulation and had steroid levels at trigger available. Mean E at trigger was 3449 ± 2040 pg/mL while mean P was 1.13 ± 0.58 ng/mL, with mean E/P of 3.36 + 2.04. There were no differences between quartiles of E/P with respect to retrieval, maturity rate, or euploid rate. Two hundred eleven IVF cycles resulted in 138 euploid frozen embryo transfers. There were no differences between quartiles of E/P with respect to clinical pregnancy, ongoing pregnancy, or live birth rate.

conclusionE/P ratio at the time of trigger does not impact oocyte retrieval rate, maturity rate, or euploid rate. Pregnancy and live birth outcomes were also not impacted.

Indexed as

EstradiolProgesteroneFemaleHumansLive BirthOocytesOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesEstradiolProgesteroneEstradiol to progesterone ratioLive birth rateOocyte maturity rateOvulation induction

Identifiers

PMID35672539
PMCPMC9365892
OpenAlexW4281922640

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.