Evidence map›Paper›PMID 35672408›Full record

ArticleNature communications2022

Molecular basis of mEAK7-mediated human V-ATPase regulation.

Rong Wang, Yu Qin, Xiao-Song Xie, Xiaochun Li

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Interaction of yeast V-ATPase with TLDc protein Rtc5p.bioRxiv : the preprint server for biology · 2025
    Article
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  11. Tender love and disassembly: How a TLDc domain protein breaks the V-ATPase.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rong WangDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0001-7342-5278
Yu QinDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Xiao-Song XieEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0001-7013-4571
Xiaochun LiDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. xiaochun.li@utsouthwestern.edu.ORCID 0000-0002-0177-0803
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
Role of ABCG5 and ABCG8 in Sterol MetabolismR01HL072304 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HOBBS, HELEN HASKELL · 2003 to 2025
$7.0M
Structural and Functional investigations of Hedgehog Signaling TransductionR01GM135343 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LI, XIAOCHUN · 2019 to 2022
$1.2M
NHLBI NIH HHS P01 HL020948NHLBI NIH HHS R01 HL072304NIGMS NIH HHS R01 GM135343
6 · The paper itself

Abstract

The activity of V-ATPase is well-known to be regulated by reversible dissociation of its V

Indexed as

Vacuolar Proton-Translocating ATPasesHumansIntracellular Signaling Peptides and ProteinsProtein SubunitsIntracellular Signaling Peptides and ProteinsMEAK7 protein, humanProtein SubunitsVacuolar Proton-Translocating ATPases

Identifiers

PMID35672408
PMCPMC9174246
OpenAlexW4282048396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.