ArticleScientific reports2022
Isolation, characterization and biological activities of betulin from Acacia nilotica bark.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Chitosan-mediated nano-bioprocessing of Acacia seyal seed extract for enhanced antineoplastic, anti-Helicobacter pylori and antioxidant performance.Bioresources and bioprocessing · 2026Article
- Chemical composition, antioxidant and antimicrobial activities, and molecular docking of Acacia gerrardii leaf extract.Scientific reports · 2026Article
- New Difunctional Derivatives of Betulin: Preparation, Characterization and Antiproliferative Potential.Molecules (Basel, Switzerland) · 2025Article
- The Acacia (Nutrients · 2024Review
- Therapeutic Role of Secondary Metabolites from Probiotic Strains for Ehrlich Solid Tumors in Mice.Current microbiology · 2024Article
- Pharmacognostic Evaluation, Chemical Characterization, and Antibacterial Activity ofPlants (Basel, Switzerland) · 2024Article
- Cistus, Acacia, and Lemon verbena Valorization through Response Surface Methodology: Optimization Studies and Potential Application in the Pharmaceutical and Nutraceutical Industries.Pharmaceuticals (Basel, Switzerland) · 2024Article
- A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish PlantMolecules (Basel, Switzerland) · 2024Article
- Efficacy of a vaginal suppository formulation prepared withFrontiers in pharmacology · 2024Article
- The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents.Journal of agricultural and food chemistry · 2023Review
- Pharmacological Potential of Betulin as a Multitarget Compound.Biomolecules · 2023Review
- Article
- Pharmacological Evaluation ofJournal of functional biomaterials · 2023Article
- Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin.Pharmaceutics · 2022Article
- New Betulin Derivatives with Nitrogen Heterocyclic Moiety-Synthesis and Anticancer Activity In Vitro.Biomolecules · 2022Article
- Antioxidant Activity of New Copolymer Conjugates of Methoxyoligo(Ethylene Glycol)Methacrylate and Betulin Methacrylate with Cerium Oxide NanoparticlesMolecules (Basel, Switzerland) · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medicinal plants are in use of humankind since ancient and still they are playing an important role in effective and safer natural drug delivery systems. Acacia nilotica (native of Egypt) commonly known as babul belongs to family Fabaceae, widely spread in India, Sri Lanka and Sudan. Being a common and important plant, using in many ways from fodder (shoots and leaves to animals) to dyeing (leather coloration) to medicine (root, bark, leaves, flower, gum, pods). The present study is focused on investigating the natural chemistry and important biological activities of the plant. Employing bioassay guided fractionation coupled with TLC and column chromatography, a pure fraction named AN-10 was isolated from ethyl acetate fraction of crude methanol extract which identified as "Betulin (Lupan-3ß,28-diol)" by Liebermann-Burchard test and structure elucidation by UV-Vis, NMR and MS techniques. A battery of in vitro biological assays for antioxidant, anti-inflammatory and anticancer were performed and betulin showed excellent potential in all assays. It was found that the inhibitory potential in all assays were dose dependent manner and after a range of concentration, the activities get leveled off with no further increase in activity.
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