Evidence map›Paper›PMID 35672343›Full record

ArticleScientific reports2022

A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis.

Monir Ejemel, Todd G Smith, Lauren Greenberg, William C Carson, David Lowe, Yong Yang, Felix R Jackson, Clint N Morgan, Brock E Martin, Chantal Kling and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Monir Ejemel *MassBiologics of the University of Massachusetts Chan Medical School, 460 Walk Hill, Boston, MA, 02126, USA.
Todd G Smith *Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA. tgsmith1@cdc.gov.
Lauren GreenbergPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
William C CarsonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
David LowePoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Yong YangPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Felix R JacksonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Clint N MorganPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Brock E MartinPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Chantal KlingPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Christina L HutsonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Nadia Gallardo-RomeroPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
James A EllisonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30329, USA.
Susan MooreVeterinary Diagnostic Laboratory, Rabies Laboratory, Kansas State University, Manhattan, KS, 66502, USA.
Adam BuzbyMassBiologics of the University of Massachusetts Chan Medical School, 460 Walk Hill, Boston, MA, 02126, USA.
John Sullivan-BolyaiMassBiologics of the University of Massachusetts Chan Medical School, 460 Walk Hill, Boston, MA, 02126, USA.
Mark KlempnerMassBiologics of the University of Massachusetts Chan Medical School, 460 Walk Hill, Boston, MA, 02126, USA.
Yang WangMassBiologics of the University of Massachusetts Chan Medical School, 460 Walk Hill, Boston, MA, 02126, USA. yang.wang@umassmed.edu.
Centers for Disease Control and Prevention · USUniversity of Massachusetts Chan Medical School · USApellis Pharmaceuticals (United States) · USKansas State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), a passive component of rabies post-exposure prophylaxis (PEP), with a monoclonal antibody (MAb), would eliminate the cost and availability constraints associated with RIG. Our team has developed and licensed a human monoclonal antibody RAB1 (Rabishield

Indexed as

Antineoplastic Agents, ImmunologicalRabiesRabies VaccinesRabies virusAnimalsAntibodies, MonoclonalAntibodies, ViralDogsHumansPost-Exposure ProphylaxisAntibodies, MonoclonalAntibodies, ViralAntineoplastic Agents, ImmunologicalRabies Vaccines

Identifiers

PMID35672343
PMCPMC9174473
OpenAlexW4281744232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.