ArticleNature communications2022
Serotonin and dopamine modulate aging in response to food odor and availability.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
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- Unlocking neuronal health: leveraging C. elegans for drug repurposing studies.Cell communication and signaling : CCS · 2026Review
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Serotonin drives fat storage via 5-HT7 signaling in Drosophila.Genes & genomics · 2026Article
- Rewarding touch limits lifespan through neural to intestinal signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Metabolic regulation of behavior by the intestinal enzyme FMO-2.Science advances · 2025Article
- Unlocking the longevity code with stress.eLife · 2025Article
- The dopaminergic system ofRoyal Society open science · 2025Review
- The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.bioRxiv : the preprint server for biology · 2025Article
- Tradeoffs in the energetic value of neuromodulation in a closed-loop neuromechanical system.Journal of theoretical biology · 2025Article
- Modulation of C. elegans behavior, fitness, and lifespan by AWB/ASH-dependent death perception.Current biology : CB · 2025Article
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- findWormz is a user-friendly automated fluorescence quantification method formicroPublication biology · 2025Article
- Perception ofmicroPublication biology · 2025Article
- Fmo induction as a tool to screen for pro-longevity drugs.GeroScience · 2024Article
- Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology.bioRxiv : the preprint server for biology · 2024Article
- A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan inScience advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
An organism's ability to perceive and respond to changes in its environment is crucial for its health and survival. Here we reveal how the most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-autonomous signaling pathway that is inhibited by the presence of attractive smells. Using an intestinal reporter for a key gene induced by dietary restriction but suppressed by attractive smells, we identify three compounds that block food odor effects in C. elegans, thereby increasing longevity as dietary restriction mimetics. These compounds clearly implicate serotonin and dopamine in limiting lifespan in response to food odor. We further identify a chemosensory neuron that likely perceives food odor, an enteric neuron that signals through the serotonin receptor 5-HT1A/SER-4, and a dopaminergic neuron that signals through the dopamine receptor DRD2/DOP-3. Aspects of this pathway are conserved in D. melanogaster. Thus, blocking food odor signaling through antagonism of serotonin or dopamine receptors is a plausible approach to mimic the benefits of dietary restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.