Evidence map›Paper›PMID 35672073›Full record

ArticleBMJ open2022

Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan.

Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Aoi NodaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID 0000-0002-7644-6848
Mami IshikuroTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID 0000-0002-2884-0023
Taku ObaraTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan obara-t@hosp.tohoku.ac.jp.
Keiko MurakamiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Fumihiko UenoTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Fumiko MatsuzakiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Tomomi OnumaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Zen WatanabeDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Naomi ShigaDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Noriyuki IwamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Hamada HirotakaDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, Japan.ORCID 0000-0002-6397-5898
Tatsui OtsukaDepartment of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Masahito TachibanaDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Hiroaki TomitaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Masatoshi SaitoDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Junichi SugawaraTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID 0000-0001-8026-2550
Shigeo KureTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Nobuo YaegashiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Shinichi KuriyamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Tohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age.

designProspective cohort study. SETTING AND

participantsThe study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3.

resultsOf 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37).

conclusionIn this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.

Indexed as

InfertilityReproductive Techniques, AssistedChild, PreschoolCohort StudiesFemaleHumansJapanMalePregnancyProspective Studiesdevelopmental neurology & neurodisabilityepidemiologymaternal medicine

Identifiers

PMID35672073
PMCPMC9174802
OpenAlexW4281857276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.