ArticleBrain stimulation
Effects of stimulus pulse rate on somatosensory adaptation in the human cortex.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Long-term safety and efficacy of intracortical microstimulation in humans.Science translational medicine · 2026Trial
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation.Journal of neural engineering · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Neural correlates of phosphene perception in blind individuals: A step toward a bidirectional cortical visual prosthesis.Science advances · 2025Article
- Visual context affects the perceived timing of tactile sensations elicited through intracortical microstimulation: a case study of two participants.Journal of neurophysiology · 2025Article
- Toward Natural Limb Function: A New Era in Prosthetic Innovation.Annals of neurology · 2025Review
- Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025Article
- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Expectation Of Tactile Signals In Human Motor Cortex.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.Nature biomedical engineering · 2025Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Visual context affects the perceived timing of tactile sensations elicited through intra-cortical microstimulation.bioRxiv : the preprint server for biology · 2024Article
- Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases.medRxiv : the preprint server for health sciences · 2024Article
- Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex.Journal of neural engineering · 2024Article
- Neuromorphic hardware for somatosensory neuroprostheses.Nature communications · 2024Review
- Sensory Restoration for Improved Motor Control of Prostheses.Current opinion in biomedical engineering · 2023Article
- Biomimetic multi-channel microstimulation of somatosensory cortex conveys high resolution force feedback for bionic hands.bioRxiv : the preprint server for biology · 2023Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntracortical microstimulation (ICMS) of the somatosensory cortex can restore sensation to people with neurological diseases. However, many aspects of ICMS are poorly understood, including the effect of stimulation on percept intensity over time.
objectiveHere, we evaluate how tactile percepts evoked by ICMS in the somatosensory cortex of a human participant adapt over time.
methodsWe delivered continuous and intermittent ICMS to the somatosensory cortex and assessed the reported intensity of tactile percepts over time in a human participant. Experiments were conducted over approximately one year and linear mixed effects models were used to assess significance.
resultsContinuous stimulation at high frequencies led to rapid decreases in intensity, while low frequency stimulation maintained percept intensity for longer periods. Burst-modulated stimulation extended the time before the intensity began to decrease, but all protocols ultimately resulted in complete sensation loss within 1 min. Intermittent stimulation paradigms with several seconds between stimulus trains evoked intermittent percepts and also led to decreases in intensity on many electrodes, but never resulted in extinction of the sensation after over 3 min of stimulation. Longer breaks between each pulse train resulted in some recovery in the intensity of the stimulus-evoked percepts. For several electrodes, intermittent stimulation had almost no effect on the perceived intensity.
conclusionsIntermittent ICMS paradigms were more effective at maintaining percepts. Given that transient neural activity dominates the response in somatosensory cortex during mechanical contact onsets and offsets, providing brief stimulation trains at these times may more closely represent natural cortical activity and have the additional benefit of prolonging the ability to evoke sensations over longer time periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.