Evidence map›Paper›PMID 35671352›Full record

ArticleACS chemical neuroscience2022

Optimized Administration of the M

Jakub Cikowski, Calista Holt, Bright Arthur, Mackenzie Smith, Sonia Gonzalez, Craig W Lindsley, Colleen M Niswender, Rocco G Gogliotti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Reciprocal regulation of the HbioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Activation of MBritish journal of pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jakub CikowskiDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, United States.
Calista HoltDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, United States.
Bright ArthurDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Mackenzie SmithDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, United States.
Sonia GonzalezDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, United States.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0003-0168-1445
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Rocco G GogliottiDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, United States.ORCID 0000-0003-0254-7643
Loyola University Chicago · USVanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
A precision medicine approach to Rett SyndromeR01NS112171 · NINDS · LOYOLA UNIVERSITY CHICAGO · PI GOGLIOTTI, ROCCO GEORGE · 2020 to 2024
$1.7M
Normalizing E:I imbalance in Rett Syndrome by Modulation of Late Response GenesK01MH112983 · NIMH · VANDERBILT UNIVERSITY · PI GOGLIOTTI, ROCCO GEORGE · 2017 to 2020
$543k
NICHD NIH HHS P50 HD103537NIMH NIH HHS K01 MH112983NINDS NIH HHS R01 NS112171
6 · The paper itself

Abstract

Hypofunction of cholinergic circuits and diminished cholinergic tone have been associated with the neurodevelopmental disorder Rett syndrome (RTT). Specifically, deletion of

Indexed as

PyridazinesRett SyndromeAnimalsCholinergic AgentsDisease Models, AnimalMethyl-CpG-Binding Protein 2MiceMice, KnockoutThiophenes5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno(2,3-c)pyridazine-6-carboxamideCholinergic AgentsMecp2 protein, mouseMethyl-CpG-Binding Protein 2PyridazinesThiophenesapneasbrainstemGsk3βM4 mAChRRett syndrometolerance

Identifiers

PMID35671352
PMCPMC9266622
OpenAlexW4281983535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.