ArticlePloS one2022
Multimorbidity and depression among older adults in India: Mediating role of functional and behavioural health.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Prevalence of depressive symptoms, anxiety, sleep & substance use disorders among older adults in LMICs: A systematic review & meta-analysis.The Indian journal of medical research · 2025Pooled it
- Prevalence and factors influencing depression among empty nesters in China: A meta-analysis.BMC geriatrics · 2023Pooled it
- Multidimensional determinants of depression and non-depression in older adults: evidence from national data.BMC geriatrics · 2026Article
- Age-based discrimination and healthcare utilization among older adults in India: a sequential mediation model with rural-urban differences.BMC geriatrics · 2026Article
- The interplay of multimorbidity and depressive symptoms: mediation role of functional dependence.Epidemiology and psychiatric sciences · 2026Article
- Depression and Multimorbidity among Older Indians Residing in Front-Runner, Achiever and Aspirant States: Insight from Longitudinal Ageing Study in India (LASI) - Wave I.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- The Ripple Effect: A Serial Mediation Analysis of Multimorbidity and Depressive Symptoms Among Women in Midlife in China.International journal of women's health · 2026Article
- Depressive symptoms among older adults in Turkey: Evidence from a nationally representative ageing survey.PloS one · 2026Article
- The impact of multimorbidity on the occurrence of depression among middle-aged and elderly people in China.PloS one · 2026Article
- The Impact of Falls on Depressive Symptoms in Middle-Aged and Older Chinese Adults: Mediating Effects of Pain.Psychology research and behavior management · 2026Article
- Predictors of a Depression Indicator in a Large Public Dataset: Logistic Regression and Neural Network Comparison.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2026Article
- A Systematic Review and Meta-analysis of the Global Prevalence of Depression in Older Adults with Multi-morbidity.Indian journal of psychological medicine · 2025Review
- Cross-national statistical harmonization of the Center for Epidemiologic Studies Depression (CES-D) scale among older adults in China, England, India, Mexico, South Africa, and the United States.Journal of clinical epidemiology · 2025Article
- Article
- Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization.Journal of multidisciplinary healthcare · 2025Article
- Multimorbidity, health Literacy, and quality of life among older adults in an urban slum in India: a community-based cross-sectional study.BMC public health · 2024Article
- Characterizing Multimorbidity Prevalence and Adverse Outcomes in Ethnically and Culturally Diverse Sub-Populations in India: Gaps, Opportunities, and Future Directions.International journal of environmental research and public health · 2024Review
- Association of perceived childhood socio-economic status and health with depressive symptoms among middle-aged and older adults in India: using data from LASI Wave I, 2017-2018.BMC geriatrics · 2024Article
- Chronic disease and multimorbidity in the Chinese older adults' population and their impact on daily living ability: a cross-sectional study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).Archives of public health = Archives belges de sante publique · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Researchers have long been concerned about the association between depression and the prevalence of multiple chronic diseases or multimorbidity in older persons. However, the underlying pathway or mechanism in the multimorbidity-depression relationship is still unknown. Data were extracted from a baseline survey of the Longitudinal Ageing Survey of India (LASI) conducted during 2017-18 (N = 31,464; aged ≥ 60 years). Depression was assessed using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). Multivariable logistic regression was used to examine the association. The Karlson-Holm-Breen (KHB) method was adopted for mediation analysis. The prevalence of depression among older adults was nearly 29% (men: 26% and women 31%). Unadjusted and adjusted estimates in binary logistic regression models suggested an association between multimorbidity and depression (UOR = 1.28; 95% CIs 1.27-1.44 and AOR = 1.12; 95% CIs 1.12-1.45). The association was particularly slightly strong in the older men. In addition, the association was mediated by functional health such as Self Rated Health (SRH) (proportion mediated: 40%), poor sleep (35.15%), IADL disability (22.65%), ADL disability (21.49%), pain (7.92%) and by behavioral health such as physical inactivity (2.28%). However, the mediating proportion was higher among older women as compared to older men. Physical inactivity was not found to be significant mediator for older women. The findings of this population-based study revealed that older people with multimorbidity are more likely to suffer depressive symptoms in older ages, suggesting the need for more chronic disease management and research. Multimorbidity and depression may be mediated by certain functional health factors, especially in older women. Further longitudinal research is needed to better understand the underlying mechanisms of this association so that future preventive initiatives may be properly guided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.