ArticleActa bio-medica : Atenei Parmensis2022
Total Knee Replacement in Alkaptonuric Ochronosis.
Article in Acta bio-medica : Atenei Parmensis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 0 citations in OpenAlex.
- Incidental Discovery of Ochronosis During Total Knee Arthroplasty: A Case Report and Literature Review.Arthroplasty today · 2026Article
- Total Knee Arthroplasty in Alkaptonuric Patient With Ochronotic Arthropathy.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Blackish Discoloration of Articular Cartilage during Total Knee Replacement; a Case Report.Journal of orthopaedic case reports · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveAlkaptonuria is a rare disease characterized by the accumulation of homogentisic acid (HGA). Over time, these patients may develop disabling ochronotic arthropathy. We present 2 cases of patients with end-stage arthropathy treated with total knee arthroplasty (TKA).
methodsBoth patients complained of disabling knee pain and reported limited walking distance (200-300 m). One had a history of osteotomy for medial knee arthtritis and ignored his underlying condition. The other presented with valgus gonoarthrosis and diagnosis of alkaptonuria.
resultsIntraoperatively, the characteristic dark-blue color in the joint was observed. Both patients evolved favorably after TKA with excellent results according to the Knee Society Scores (KSS) at three years of follow-up.
conclusionWe believe TKA is the right treatment for patients with end-stage disease because it offers considerable relief from pain and allows patients to recover function.
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