ArticleEuropean journal of pain (London, England)2022
Pain-autonomic interaction is a reliable measure of pain habituation in healthy subjects.
Article in European journal of pain (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- The role of biopsychosocial factors in classifying pain intensity across various chronic pain conditions.Scientific reports · 2026Article
- Lower thresholds and stronger adaptation to pain in musicians reflect occupational-specific adaptations to contact heat stimulation.European journal of pain (London, England) · 2025Article
- Understanding inter-individual variability of experimental pain habituation and conditioned pain modulation in healthy individuals.Scientific reports · 2024Article
- Posttraumatic headache: pain related evoked potentials (PREP) and conditioned pain modulation (CPM) to assess the pain modulatory function.Scientific reports · 2024Article
- Pain-autonomic measures reveal nociceptive sensitization in complex regional pain syndrome.European journal of pain (London, England) · 2023Article
- Pain-autonomic interaction is a reliable measure of pain habituation in healthy subjects.European journal of pain (London, England) · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHabituation is a response decrement resulting from repeated stimuli. Reduced habituation to noxious stimuli is considered to be a proxy for central sensitization in subjects with chronic pain. Despite numerous investigations of pain habituation in relation to central sensitization, there is no consensus on the most sensitive and reliable readout, as well as analysis approach. Therefore, this study compared the usability and reliability of different readouts and habituation analysis approaches to measure pain habituation in response to repetitive heat simulation.
methodsThree blocks of 20 contact heat stimuli were applied on the volar forearm of 20 healthy subjects on two separate visits. Habituation was assessed by three different readouts: pain ratings, contact heat evoked potentials (CHEPs) and heat-induced sympathetic skin responses (SSRs). In addition, two different habituation analysis approaches were used: between the three stimulation blocks (between-block) and within the first stimulation block (within-block).
resultsSignificant between-block habituation for SSRs (p < 0.001), but not for pain ratings (p = 1.000) and CHEPs (p = 0.078) was found. There was significant within-block habituation for pain ratings (p = 0.012) and SSRs (p < 0.001), but not for CHEPs (p = 0.246). Only the between-block habituation of heat-induced SSR was reliable between the two visits (first to second block: intraclass correlation coefficient [ICC] = 0.58, p = 0.030; first to third block: ICC = 0.64, p = 0.015).
conclusionHeat-induced SSR as a measure of pain-autonomic interaction revealed the strongest pain habituation and showed the highest test-retest reliability.
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