SynthesisMetabolic brain disease2022
The relationship between uric acid and brain health from observational studies.
Synthesis in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Pooled it
- Uric acid levels and risk of cognitive impairment: Dose-response meta-analysis of prospective cohort studies.PloS one · 2023Pooled it
- ASGR2 and CLEC12A as Prognostically Relevant C-Type Lectin Hubs in Glioblastoma.International journal of molecular sciences · 2026Article
- Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- High serum uric acid levels explains the negative impact of the altitude adaptation index on the brain electroencephalographic Microstate D under high-altitude hypoxic conditions.Frontiers in integrative neuroscience · 2026Article
- Article
- Clinical information prompt-driven retinal fundus image for brain health evaluation.Military Medical Research · 2025Observational
- Hyperuricemia in Chinese Patients with Mood Disorders: Prevalence, Related Factors, and Predictive Model.Neuropsychiatric disease and treatment · 2025Article
- Hyperuricemia reduces the risk of MCI but not dementia: a cross-sectional study in Liuyang.Frontiers in neurology · 2025Article
- The association between serum uric acid and depression among U.S. National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases.Current pharmaceutical design · 2025Review
- Cognitive function and uric acid levels among low-income rural Chinese aged ≥60 years without hyperuricemia.Frontiers in medicine · 2025Article
- Associations between elevated uric acid and brain imaging abnormalities in pediatric patients with methylmalonic acidemia under 5 years of age.Scientific reports · 2024Article
- Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study.BMC medicine · 2024Article
- Association of serum uric acid with functional disability in older subjects: a population-based study.Aging clinical and experimental research · 2024Article
- Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study.Frontiers in medicine · 2024Article
- Microbiota-gut-liver-brain axis and hepatic encephalopathy.Microbiome research reports · 2024Review
- Association of gout with brain reserve and vulnerability to neurodegenerative disease.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study conducts a systematic literature review and meta-analysis regarding the potential influence of serum uric acid levels on cerebral small vessel diseases and the cognitive status in the prodromal stages of dementia. We identified four different cerebral small vessel diseases and three specific domains of cognitive performance to be considered in the literature search. The analysis contained 14 studies (13 cross-sectional design and one longitudinal design) with 11,502 participants measuring the relationship between uric acid and cerebral small vessel disease. In both continuous and categorical analyses, significant associations were found between hyperuricemia and cerebral small vessel diseases (continuous data: pooled OR: 1.00, 95%CI: 1.00-1.01 and categorical data: pooled OR: 1.42, 95%CI: 1.15-1.75). For the relationship between uric acid and cognitive performance, 19 studies with 49,901 participants were considered, including eight cohort studies, and 11 cross-sectional studies. The cross-sectional data showed that a marginal relationship existed between uric acid and global cognition (β: 0.00, 95%CI: -0.01-0.00). The pooled analysis of cohort studies indicated that higher uric acid had a deleterious effect on attention and executive function (continuous data: β: -0.02, 95%CI: -0.04-0.00 and categorical data: β: -0.03, 95%CI: -0.07-0.00). Conclusion: Our study indicated that a higher level of uric acid had an adverse effect on brain health. Furthermore, a high level of uric acid is related to cognitive decline in attention and executive function, which may exist a long time before the diagnosis of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.