Evidence map›Paper›PMID 35670987›Full record

Trial reportAIDS and behavior2022

Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV.

K Rivet Amico, Jane C Lindsey, Michael Hudgens, Ronald Dallas, Keith J Horvath, Amanda Dunlap, Rachel Goolsby, Megan Mueller Johnson, Barbara Heckman, Jessica Crawford and 7 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

K Rivet AmicoDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA. ramico@umich.edu.ORCID http://orcid.org/0000-0002-4458-6934
Jane C LindseyCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michael HudgensDepartment of Biostatistics, Collaborative Studies Coordinating Center, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ronald DallasDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Keith J HorvathDepartment of Clinical Psychology, San Diego State University, San Diego, CA, USA.
Amanda DunlapDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Rachel GoolsbyDepartment of Biostatistics, Collaborative Studies Coordinating Center, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Megan Mueller JohnsonDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Barbara HeckmanFrontier Science and Technology Research Foundation, Amherst, NY, USA.
Jessica CrawfordDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Elizabeth SecordWayne State University, Detroit, MI, USA.
Murli PurswaniBronxCare Health System, Bronx, NY, USA.
Danial ReirdenChildren's Hospital Colorado, University of Colorado Denver, Denver, CO, USA.
Mobeen RathoreEducation and Service (UF CARES), University of Florida Center for HIV/AIDS Research, Jacksonville, FL, USA.
Lisa-Gaye RobinsonSouth Florida CDTC, Ft. Lauderdale, FL, USA.
Aditya H GaurDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
TERA Study Team
Michigan Department of Health and Human Services · USSt. Jude Children's Research Hospital · USUniversity of North Carolina at Chapel Hill · USCancer Research And Biostatistics · USChildren's Hospital Colorado · USFrontier Science & Technology Research Foundation · USMontefiore Health System · USSan Diego State University · USUniversity of Florida · USWayne State University · US

Funding

Project-003U24HD089880 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUDGENS, MICHAEL G, LAVANGE, LISA · 2016 to 2021
$44.3M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U24HD089880NICHD NIH HHS U24 HD089880
6 · The paper itself

Abstract

Youth living with HIV (YLWH) in the US have low rates of viral suppression (VS). In a prospective randomized clinical trial (ATN152) that enrolled 89 YLWH on antiretroviral therapy (ART) with detectable viral load, we evaluated a 12 week triggered escalating real-time adherence (TERA) intervention with remote coaching, electronic dose monitoring (EDM), and outreach for missed/delayed doses compared to standard of care (SOC). Median [Q1, Q3] percent days with EDM opening was higher in TERA (72% (47%, 89%)) versus SOC (41% (21%, 59%); p < 0.001) and incidence of numbers of 7 day gaps between openings were lower (TERA to SOC ratio: 0.40; 95% CI 0.30, 0.53; p < 0.001). There were no differences in VS at week 12 (TERA 35%; 95% CI 21%, 51% versus SOC 36%; 95% CI 22%, 51%; p > 0.99) or later time-points. The intervention improved adherence but not VS in heavily ART-experienced YLWH. Remote coaching more closely tailored to the unique dosing patterns and duration of need for youth struggling to reach VS warrants further investigation.

Indexed as

Anti-HIV AgentsHIV InfectionsMentoringTelemedicineAdolescentHumansMedication AdherenceProspective StudiesViral LoadAnti-HIV AgentsCoachingEDMInterventionmHealthViral suppressionYLWHYouth

Identifiers

PMID35670987
PMCPMC9171094
OpenAlexW4281619787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.