Evidence map›Paper›PMID 35670854›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion: unique morphology akin to subsets of sinonasal low-grade non-intestinal-type adenocarcinoma.

Satsuki Kishikawa, Takuo Hayashi, Junzo Shimizu, Bungo Fuwa, Akitaka Nonomura, Tsuyoshi Saito, Yasushi Yatabe, Takashi Yao

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. ETV6::NTRK3-associated papillary adenocarcinoma: let us play it by ear.Virchows Archiv : an international journal of pathology · 2024
    Article
  2. Article
  3. Cancers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Satsuki KishikawaDepartment of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Takuo HayashiDepartment of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. tkhyz@juntendo.ac.jp.
Junzo ShimizuDepartment of Chest Surgery, Hokuriku Central Hospital, Oyabe, Toyama, 932-8503, Japan.
Bungo FuwaDepartment of Pathology, Hokuriku Central Hospital, Oyabe, Toyama, 932-8503, Japan.
Akitaka NonomuraDepartment of Pathology, Hokuriku Central Hospital, Oyabe, Toyama, 932-8503, Japan.
Tsuyoshi SaitoDepartment of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yasushi YatabeDepartment of Diagnostic Pathology, National Cancer Center, Chuo-ku, Tokyo, 104-0045, Japan.
Takashi YaoDepartment of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Juntendo University · JPHokuriku Electric Power Company (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of NTRK fusions in non-small cell carcinoma (NSCLC) is only approximately 0.2%, most of which harbor NTRK1 fusions. NSCLCs with NTRK3 fusions are extremely rare. Herein, we report a case of low-grade tracheal adenocarcinoma in a 64-year-old woman. Histologically, areas of complicated tubule-papillary or cribriform patterns constituted a major component of the tumor and comprised cuboidal to columnar epithelial tumor cells with pale eosinophilic cytoplasm and cytoplasmic mucin, similar to subsets of sinonasal low-grade non-intestinal-type adenocarcinomas. Immunohistochemically, the tumor was positive for MUC5AC and MUC4 and showed nuclear expression of the pan-Trk antibody. ETV6::NTRK3 was identified by reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissues. To the best of our knowledge, this is the first case of low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion. Our case illustrates that low-grade adenocarcinomas with ETV6::NTRK3 fusion may exist throughout the respiratory tract.

Indexed as

AdenocarcinomaCarcinomaBiomarkers, TumorFemaleHumansImmunohistochemistryMiddle AgedOncogene Proteins, FusionProto-Oncogene Proteins c-etsRepressor ProteinsBiomarkers, TumorOncogene Proteins, FusionProto-Oncogene Proteins c-etsRepressor ProteinsETV6::NTRK3 fusionTracheal adenocarcinomaTracheal tumor

Identifiers

PMID35670854
OpenAlexW4281740556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.