ArticlePlant physiology2022
HISTONE DEACETYLASE 15 and MOS4-associated complex subunits 3A/3B coregulate intron retention of ABA-responsive genes.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Splicing Factors in Plant Abiotic Stress Responses: Regulatory Mechanisms and Perspectives.Plants (Basel, Switzerland) · 2026Review
- Long-Term Salt Exposure Reprograms the Nicotiana tabacum BY-2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments.Plant, cell & environment · 2026Article
- Characterization of histone acetyltransferase and histone deacetylase genes under abiotic and hormone stresses in soybean.Frontiers in plant science · 2026Article
- Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants.Npj biological timing and sleep · 2026Article
- Mago nashi controls auxin-mediated embryo patterning in Arabidopsis by regulating transcript abundance.The New phytologist · 2025Article
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- MAC3A and MAC3B mediate degradation of the transcription factor ERF13 and thus promote lateral root emergence.The Plant cell · 2024Article
- Mechanisms of Plant Epigenetic Regulation in Response to Plant Stress: Recent Discoveries and Implications.Plants (Basel, Switzerland) · 2024Review
- Plant responses to abiotic stress regulated by histone acetylation.Frontiers in plant science · 2024Review
- Comparative transcriptomic analyses of diploid and tetraploid citrus reveal how ploidy level influences salt stress tolerance.Frontiers in plant science · 2024Article
- Histone Deacetylase Complex 1 and histone 1 epigenetically moderate stress responsiveness of Arabidopsis thaliana seedlings.The New phytologist · 2024Article
- Co-condensation with photoexcited cryptochromes facilitates MAC3A to positively control hypocotyl growth inScience advances · 2023Article
- Plant Intron-Splicing Efficiency Database (PISE): exploring splicing of ∼1,650,000 introns in Arabidopsis, maize, rice, and soybean from ∼57,000 public RNA-seq libraries.Science China. Life sciences · 2023Article
- Histone Deacetylase HDA15 Restrains PHYB-Dependent Seed Germination via Directly RepressingCells · 2022Article
- Histone variants and modifications during abiotic stress response.Frontiers in plant science · 2022Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone deacetylases (HDAs) play an important role in transcriptional regulation of multiple biological processes. In this study, we investigated the function of HDA15 in abscisic acid (ABA) responses. We used immunopurification coupled with mass spectrometry-based proteomics to identify proteins interacting with HDA15 in Arabidopsis (Arabidopsis thaliana). HDA15 interacted with the core subunits of the MOS4-associated complex (MAC), MAC3A and MAC3B, with interaction between HDA15 and MAC3B enhanced by ABA. hda15 and mac3a/mac3b mutants were ABA-insensitive during seed germination and hyposensitive to salinity. RNA sequencing analysis demonstrated that HDA15 and MAC3A/MAC3B co-regulate ABA-responsive intron retention (IR). Furthermore, HDA15 reduced the histone acetylation level of genomic regions near ABA-responsive IR sites and the association of MAC3B with ABA-responsive pre-mRNA was dependent on HDA15. Our results indicate that HDA15 is involved in ABA responses by interacting with MAC3A/MAC3B to mediate splicing of introns.
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