Evidence map›Paper›PMID 35670732›Full record

ArticleOrganic letters2022

A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines.

Xianke Sang, Feifei Tong, Zhigang Zeng, Minghu Wu, Bo Yuan, Zhoutong Sun, Xiang Sheng, Ge Qu, Miguel Alcalde, Frank Hollmann and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Xianke SangSchool of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, 88 Xianning Avenue, Xianning, Hubei 437100, China.
Feifei TongTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.
Zhigang ZengSchool of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, 88 Xianning Avenue, Xianning, Hubei 437100, China.ORCID 0000-0002-1048-1499
Minghu WuSchool of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, 88 Xianning Avenue, Xianning, Hubei 437100, China.
Bo YuanTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.ORCID 0000-0001-5311-0738
Zhoutong SunTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.ORCID 0000-0002-9923-0951
Xiang ShengTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.ORCID 0000-0002-6542-6649
Ge QuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.ORCID 0000-0002-0711-169X
Miguel AlcaldeDepartment of Biocatalysis, Institute of Catalysis, CSIC, 28049 Madrid, Spain.ORCID 0000-0001-6780-7616
Frank HollmannDepartment of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629HZ Delft, The Netherlands.ORCID 0000-0003-4821-756X
Wuyuan ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin 300308, China.ORCID 0000-0002-3182-5107
Chinese Academy of Sciences · CNHubei University of Science and Technology · CNDelft University of Technology · NLInstituto de Catálisis y Petroleoquímica · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propargylic alcohols and amines are versatile building blocks in organic synthesis. We demonstrate a straightforward enzymatic cascade to synthesize enantiomerically pure propargylic alcohols and amines from readily available racemic starting materials. In the first step, the peroxygenase from

Indexed as

Alcohol DehydrogenaseAminesAlcoholsBiocatalysisStereoisomerismTransaminasesAlcohol DehydrogenaseAlcoholsAminesTransaminases

Identifiers

PMID35670732
PMCPMC9208015
OpenAlexW4281764309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.