Evidence map›Paper›PMID 35670711›Full record

ArticleCancer immunology research2022

All Glioblastoma Are Not Equal: Distinct Spatial Immune Profiles Between De Novo and Recurrent Tumors.

Defne Bayik, Juyeun Lee, Justin D Lathia

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Cancer immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Defne Bayik *Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0002-4740-8869
Juyeun Lee *Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0001-8276-5020
Justin D LathiaLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0003-3168-7290

Funding

Sex-specific differences in the tumor microenvironment alter glioblastoma growthP01CA245705 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Jingqin Luo · 2020 to 2026
$15.0M
Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in GlioblastomaR35NS127083 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Justin D. Lathia · 2022 to 2026
$3.1M
Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastomaK99CA248611 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI BAYIK WATSON, DEFNE · 2021 to 2022
$241k
NCI NIH HHS K99 CA248611NCI NIH HHS P01 CA245705NINDS NIH HHS R35 NS127083
6 · The paper itself

Abstract

Lack of insight into the immunosuppressive microenvironment of glioblastoma (GBM) hinders successful application of immunotherapy. In this issue, Alanio and colleagues identify a distinct T-cell localization profile between recurrent and de novo GBM highlighting the importance of spatial heterogeneity and providing new avenues to explore to improve GBM outcome. See related article by Alanio et al., p. 800 (3).

Indexed as

Brain NeoplasmsGlioblastomaHumansImmunotherapyT-LymphocytesTumor Microenvironment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.