Evidence map›Paper›PMID 35670474›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

PTPα promotes fibroproliferative responses after acute lung injury.

Yael Aschner, Kelly A Correll, Keriann M Beke, Daniel G Foster, Helen M Roybal, Meghan R Nelson, Carly L Meador, Matthew Strand, Kelsey C Anderson, Camille M Moore and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Lipoxin A4 AttenuatesJournal of inflammation research · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yael AschnerDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0002-8246-1083
Kelly A CorrellDepartment of Medicine, National Jewish Health, Denver, Colorado.
Keriann M BekeDepartment of Medicine, National Jewish Health, Denver, Colorado.
Daniel G FosterDepartment of Medicine, National Jewish Health, Denver, Colorado.
Helen M RoybalDepartment of Medicine, National Jewish Health, Denver, Colorado.
Meghan R NelsonDepartment of Medicine, National Jewish Health, Denver, Colorado.
Carly L MeadorDepartment of Medicine, National Jewish Health, Denver, Colorado.
Matthew StrandDivision of Biostatistics, National Jewish Health, Denver, Colorado.
Kelsey C AndersonCenter for Genes, Environment and Health, National Jewish Health, Denver, Colorado.
Camille M MooreCenter for Genes, Environment and Health, National Jewish Health, Denver, Colorado.
Paul R ReynoldsDepartment of Medicine, National Jewish Health, Denver, Colorado.
Katrina W KopfOffice of Academic Affairs, National Jewish Health, Denver, Colorado.
Ellen L BurnhamDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Gregory P DowneyDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0003-3253-5862
National Jewish Health · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Supplement: CoPARC: Colorado Pulmonary Alcohol Research CollaborativeR24AA019661 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM · 2011 to 2026
$8.5M
Institutional Career Development CoreKL2TR002534 · NCATS · UNIVERSITY OF COLORADO DENVER · PI BURNHAM, ELLEN L · 2018 to 2022
$4.6M
Proteolysis in the Pathogenesis of ARDSR01HL157424 · NHLBI · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL, RADISKY, DEREK C · 2022 to 2025
$2.8M
Checkpoint Function of PTPalpha in Pathological Fibrogenesis in the LungR01HL132950 · NHLBI · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL · 2016 to 2019
$2.0M
Phosphorylation Control of Fibroproliferative ARDSK08HL135279 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ASCHNER, YAEL · 2019 to 2023
$810k
Targeting PTPalpha to Prevent Lung FibrosisR21ES023932 · NIEHS · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL · 2014 to 2015
$436k
NCATS NIH HHS KL2 TR002534NHLBI NIH HHS K08 HL135279NHLBI NIH HHS R01 HL132950NHLBI NIH HHS R01 HL157424NIAAA NIH HHS R24 AA019661NIEHS NIH HHS R21 ES023932
6 · The paper itself

Abstract

The acute respiratory distress syndrome (ARDS) is a major healthcare problem, accounting for significant mortality and long-term disability. Approximately 25% of patients with ARDS will develop an overexuberant fibrotic response, termed fibroproliferative ARDS (FP-ARDS) that portends a poor prognosis and increased mortality. The cellular pathological processes that drive FP-ARDS remain incompletely understood. We have previously shown that the transmembrane receptor-type tyrosine phosphatase protein tyrosine phosphatase-α (PTPα) promotes pulmonary fibrosis in preclinical murine models through regulation of transforming growth factor-β (TGF-β) signaling. In this study, we examine the role of PTPα in the pathogenesis of FP-ARDS in a preclinical murine model of acid (HCl)-induced acute lung injury. We demonstrate that although mice genetically deficient in PTPα (

Indexed as

Acute Lung InjuryPulmonary FibrosisReceptor-Like Protein Tyrosine Phosphatases, Class 4Respiratory Distress SyndromeAnimalsLungMicePhosphoric Monoester HydrolasesTransforming Growth Factor betaPhosphoric Monoester HydrolasesPtpra protein, mouseReceptor-Like Protein Tyrosine Phosphatases, Class 4Transforming Growth Factor betaacute lung injuryARDSfibroproliferative ARDSPTPα

Identifiers

PMID35670474
PMCPMC9255711
OpenAlexW4282027636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.