Evidence map›Paper›PMID 35670372›Full record

ArticleParasitology2022

Ageing impairs protective immunity and promotes susceptibility to murine visceral leishmaniasis.

Caio Loureiro Salgado, Andrés Felipe Mendéz Corea, Luciana Polaco Covre, Herbet Leonel De Matos Guedes, Aloisio Falqueto, Daniel Cláudio Oliviera Gomes

Abstract read
In one paragraph

Article in Parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. The role of KLRG1: a novel biomarker and new therapeutic target.Cell communication and signaling : CCS · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caio Loureiro SalgadoNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Andrés Felipe Mendéz CoreaNúcleo de Biotecnologia, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Luciana Polaco CovreDivision of Medicine, University College London, London, UK.
Herbet Leonel De Matos GuedesInstituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0002-3819-3069
Aloisio FalquetoDepartamento de Medicina Social, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Daniel Cláudio Oliviera GomesNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.ORCID 0000-0002-0663-0981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well accepted that the impact of diseases is generally more detrimental in elderly individuals than in younger ones. Changes in the immune system due to ageing can directly affect the ability to respond effectively to infections and may contribute to the higher morbidities and mortalities in the elderly population. Leishmaniasis is a complex of clinically unique diseases caused by obligate intracellular protozoa belonging to genus

Indexed as

Leishmania infantumLeishmaniasisLeishmaniasis, VisceralAgedAgingAnimalsCD8-Positive T-LymphocytesHumansMiceMice, Inbred BALB CInflammationLeishmania infantumsenescencevisceral leishmaniasis

Identifiers

PMID35670372
PMCPMC11010576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.