Evidence map›Paper›PMID 35670364›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Total Synthesis and Prediction of Ulodione Natural Products Guided by DFT Calculations.

Jacob S Bestwick, David J Jones, Helen E Jones, Panagiotis G Kalomenopoulos, Rafal Szabla, Andrew L Lawrence

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jacob S BestwickEaStCHEM School of Chemistry, University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0002-4201-0632
David J JonesEaStCHEM School of Chemistry, University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0003-4145-1273
Helen E JonesEaStCHEM School of Chemistry, University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0003-3511-3489
Panagiotis G KalomenopoulosEaStCHEM School of Chemistry, University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0001-6156-9776
Rafal SzablaDepartment of Physical and Quantum Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.ORCID 0000-0002-1668-8044
Andrew L LawrenceEaStCHEM School of Chemistry, University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0002-9573-5637

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A biomimetic synthetic strategy has resulted in a two-step total synthesis of (±)-ulodione A and the prediction of two potential natural products, (±)-ulodiones C and D. This work was guided by computational investigations into the selectivity of a proposed biosynthetic Diels-Alder dimerization, which was then utilized in the chemical synthesis. This work highlights how biosynthetic considerations can both guide the design of efficient synthetic strategies and lead to the anticipation of new natural products.

Indexed as

Biological ProductsCyclizationCycloaddition ReactionDensity Functional TheoryDimerizationBiological ProductsBiomimetic SynthesisCycloadditionDensity Functional CalculationsDimerizationTotal Synthesis

Identifiers

PMID35670364
PMCPMC9401604

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.