Evidence map›Paper›PMID 35670339›Full record

ArticleRecent advances in inflammation & allergy drug discovery2022

Linezolid Intoxication with Extreme Lactate Blood Levels Successfully Treated with Dialytic Treatment in ICU: A Case Report.

Lorenzo Schiavoni, Alessia Mattei, Giuseppe Pascarella, Alessandro Strumia, Antonio Nenna, Massimo Chello, Felice E Agrò

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Recent advances in inflammation & allergy drug discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lorenzo SchiavoniDepartment of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Alessia MatteiDepartment of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Giuseppe PascarellaDepartment of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Alessandro StrumiaDepartment of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Antonio NennaDepartment of Medicine, Unit of Cardiac Surgery, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Massimo ChelloDepartment of Medicine, Unit of Cardiac Surgery, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Felice E AgròDepartment of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Università Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLactic acidosis is a rare but life-threatening complication associated with prolonged linezolid therapy. No specific treatment is suggested, except for antibiotic therapy interruption. CASE REPORT: A 70-years-old woman faced severe linezolid intoxication after antibiotics therapy initiation for infection of a surgical sternal wound. The patient suffered from a severe increment of blood lactate and thrombocytopenia. She was admitted to ICU twice, and due to dialytic treatment, linezolid and lactate serum levels came back to normality.

conclusionMore studies should be conducted to evaluate the human tissue storage sites of linezolid and the influence of various factors on its clearance and plasma concentrations in critically ill patients.

Indexed as

Acidosis, LacticRenal DialysisAgedAnti-Bacterial AgentsFemaleHumansLactic AcidLinezolidAnti-Bacterial AgentsLactic AcidLinezolidantibiotics therapydialysisintensive care unit (ICU)lactatelactic acidosislinezolid toxicity

Identifiers

PMID35670339
OpenAlexW4281686496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.