Evidence map›Paper›PMID 35670301›Full record

ArticlePsychological medicine2023

Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes.

Mayron Piccolo, Emily L Belleau, Laura M Holsen, Madhukar H Trivedi, Ramin V Parsey, Patrick J McGrath, Myrna M Weissman, Diego A Pizzagalli, Kristin N Javaras

Abstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayron PiccoloMcLean Hospital, Belmont, MA 02478, USA.ORCID https://orcid.org/0000-0002-6882-7456
Emily L BelleauMcLean Hospital, Belmont, MA 02478, USA.
Laura M HolsenDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
Madhukar H TrivediDivision of Mood Disorders, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.
Ramin V ParseyNeuroscience Institute, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11733, USA.
Patrick J McGrathNew York State Psychiatric Institute & Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Myrna M WeissmanNew York State Psychiatric Institute & Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Diego A PizzagalliMcLean Hospital, Belmont, MA 02478, USA.
Kristin N JavarasMcLean Hospital, Belmont, MA 02478, USA.ORCID https://orcid.org/0000-0003-0885-2331

Funding

Establishing Moderators/Biosignatures of Antidepressant Response- Clinical CareU01MH092221 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TRIVEDI, MADHUKAR H. · 2010 to 2015
$9.7M
Biosignatures of Treatment Remission in Major DepressionU01MH092250 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCGRATH, PATRICK J, PARSEY, RAMIN V. · 2010 to 2015
$8.9M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Ghrelin Modulation of Mesolimbic Reward Signaling in Stress-induced HyperphagiaR01DK104772 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HOLSEN, LAURA MCGRATH · 2016 to 2020
$2.7M
Understanding the Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive ControlK23DK120517 · NIDDK · MCLEAN HOSPITAL · PI JAVARAS, KRISTIN N. · 2018 to 2022
$1.2M
Neural Correlates of Stress and Perceived Control in Adolescent DepressionK23MH122668 · NIMH · MCLEAN HOSPITAL · PI BELLEAU, EMILY · 2020 to 2024
$960k
NIDDK NIH HHS K23 DK120517NIDDK NIH HHS R01 DK104772NIMH NIH HHS K23 MH122668NIMH NIH HHS R37 MH068376NIMH NIH HHS U01 MH092221NIMH NIH HHS U01 MH092250
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is often accompanied by changes in appetite and weight. Prior task-based functional magnetic resonance imaging (fMRI) findings suggest these MDD phenotypes are associated with altered reward and interoceptive processing.

methodsUsing resting-state fMRI data, we compared the fractional amplitude of low-frequency fluctuations (fALFF) and seed-based connectivity (SBC) among hyperphagic (

resultsMask-restricted analyses revealed stronger fALFF in the right lateral OFC, and weaker fALFF in the right anterior insula, for hyperphagic MDD

conclusionsOur results suggest hyperphagic MDD may be associated with altered activity in and connectivity between interoceptive and reward regions.

Indexed as

Major Depressive DisorderAppetiteBrainBrain MappingHumansMagnetic Resonance ImagingPhenotypeAppetiteeatingfMRImajor depressive disorderweight change

Identifiers

PMID35670301
PMCPMC9949733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.