Evidence map›Paper›PMID 35670265›Full record

ReviewPrenatal diagnosis2022

Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging.

Megan Hall, Jana Hutter, Natalie Suff, Carla Avena Zampieri, Rachel M Tribe, Andrew Shennan, Mary Rutherford, Lisa Story

Abstract readReview
In one paragraph

Review in Prenatal diagnosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megan HallDepartment of Women and Children's Health, St Thomas' Hospital, King's College, London, UK.ORCID 0000-0003-2756-6365
Jana HutterCentre for the Developing Brain, St Thomas' Hospital, King's College, London, UK.
Natalie SuffDepartment of Women and Children's Health, St Thomas' Hospital, King's College, London, UK.
Carla Avena ZampieriCentre for the Developing Brain, St Thomas' Hospital, King's College, London, UK.
Rachel M TribeDepartment of Women and Children's Health, St Thomas' Hospital, King's College, London, UK.
Andrew ShennanDepartment of Women and Children's Health, St Thomas' Hospital, King's College, London, UK.
Mary RutherfordCentre for the Developing Brain, St Thomas' Hospital, King's College, London, UK.
Lisa StoryDepartment of Women and Children's Health, St Thomas' Hospital, King's College, London, UK.

Funding

Health Education England/National Institute for health Research 301664NIH Human Placenta Project 1U01HD087202-01UKRI, FLF MR/T018119/1Wellcome/EPSRC Centre for Medical Engineering WT203148/Z/16/ZWellcome Trust, Sir Henry Wellcome Fellowship 201374/Z/16/Z
6 · The paper itself

Abstract

Chorioamnionitis is present in up to 70% of spontaneous preterm births. It is defined as an acute inflammation of the chorion, with or without involvement of the amnion, and is evidence of a maternal immunological response to infection. A fetal inflammatory response can coexist and is diagnosed on placental histopathology postnatally. Fetal inflammatory response syndrome (FIRS) is associated with poorer fetal and neonatal outcomes. The only antenatal diagnostic test is amniocentesis which carries risks of miscarriage or preterm birth. Imaging of the fetal immune system, in particular the thymus and the spleen, and the placenta may give valuable information antenatally regarding the diagnosis of fetal inflammatory response. While ultrasound is largely limited to structural information, MRI can complement this with functional information that may provide insight into the metabolic activities of the fetal immune system and placenta. This review discusses fetal and placental imaging in pregnancies complicated by chorioamnionitis and their potential future use in achieving non-invasive antenatal diagnosis.

Indexed as

ChorioamnionitisPremature BirthAmniocentesisFemaleFetal DiseasesHumansInfant, NewbornPlacentaPregnancySystemic Inflammatory Response Syndrome

Identifiers

PMID35670265
PMCPMC9543023

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.