ArticleACR open rheumatology2022
Systemic Lupus Erythematosus Delivery Outcomes Are Unchanged Across Three Decades.
Article in ACR open rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Fertility and Birth Outcomes in Rheumatoid Arthritis: A Narrative Review.Rheumatology and therapy · 2026Review
- Racial differences in cardiovascular events and adverse pregnancy outcomes among pregnant individuals with SLE.Lupus science & medicine · 2026Article
- Nationwide Temporal Trends in Adverse Pregnancy Outcomes and Treatments in Systemic Lupus Erythematosus Pregnancy Over Two Decades in Sweden.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Temporal trends in lupus pregnancy over four decades in a referral centre: pregnancy planning and hydroxychloroquine use are associated with improved outcomes.Rheumatology advances in practice · 2026Article
- Adverse pregnancy outcome associations among women prior to a diagnosis of systemic lupus erythematosus.Frontiers in lupus · 2026Article
- Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE.Lupus science & medicine · 2025Article
- Risk of preterm delivery and early pregnancy hydroxychloroquine use from a Californian lupus cohort.Lupus science & medicine · 2025Article
- A nomogram for predicting the adverse pregnancy outcomes of systemic lupus erythematosus: a single-center study.Clinical rheumatology · 2025Article
- RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus.Cell reports. Medicine · 2025Article
- The conditions that patients with systemic lupus erythematosus should fulfill before pregnancy to optimize outcomes: a large-scale multicenter cohort study from China.Arthritis research & therapy · 2025Article
- Peripartum maternal outcomes in individuals with systemic lupus erythematosus in a real-world electronic health record cohort.Seminars in arthritis and rheumatism · 2025Article
- Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study.Rheumatology (Oxford, England) · 2024Article
- Pregnancies in patients with systemic lupus erythematosus during 2000-2018 in Finland: a case-control study.Rheumatology international · 2024Article
- Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus.Arthritis research & therapy · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveUsing a large, de-identified electronic health record database with over 3.2 million patients, we aimed to identify trends of systemic lupus erythematosus (SLE) medication use during pregnancy and birth outcomes from 1989 to 2020.
methodsUsing a previously validated algorithm for SLE deliveries, we identified 255 pregnancies in patients with SLE and 604 pregnancies in controls with no known autoimmune diseases. We examined demographics, medications, SLE comorbidities, and maternal and fetal outcomes in SLE and control deliveries.
resultsCompared with control deliveries, SLE deliveries were more likely to be complicated by preterm delivery (odds ratio [OR]: 6.71; 95% confidence interval [CI]: 4.31-10.55; P < 0.001) and preeclampsia (OR: 3.22; 95% CI: 1.83-5.66; P < 0.001) after adjusting for age at delivery, race, and parity. In a longitudinal analysis, medication use during SLE pregnancies remained relatively stable, with some increased use of hydroxychloroquine over time but no increase in aspirin use. For SLE deliveries, preterm delivery and preeclampsia rates remained stable.
conclusionWe observed rates of preeclampsia and preterm delivery in SLE that were five times higher than the general population and higher compared with other prospective SLE cohorts. Furthermore, we did not observe improved outcomes over time with preeclampsia and preterm delivery. Despite increasing evidence for universal use of hydroxychloroquine and aspirin, we did not observe substantially higher use of these medications over time, particularly for aspirin. Our results demonstrate the continued need to prioritize educational and implementation efforts to improve adverse pregnancy outcomes in SLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.