ArticleTransplant international : official journal of the European Society for Organ Transplantation2022
Patient-Reported Outcomes as Endpoints in Clinical Trials of Kidney Transplantation Interventions.
Article in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients.The Cochrane database of systematic reviews · 2025Pooled it
- Beyond observed changes: how differential item functioning and response shift alter health-related quality of life interpretation in preemptive versus non-preemptive kidney transplant patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Item generation for a new disease-specific health-related quality of life questionnaire in patients with deep vein thrombosis: an international multicenter study.Research and practice in thrombosis and haemostasis · 2026Article
- Statistical analysis of Likert-based ordinal scales: a guide for clinical trialists.BMC medical research methodology · 2026Article
- First-year emotional health after liver transplantation: a prospective cohort study.Frontiers in psychology · 2026Article
- Renal Allograft Pathology Classifications: Contemporary Updates and Diagnostic Utility.Cureus · 2025Review
- Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation.Nature communications · 2025Review
- Interventions to Improve Life Participation in Kidney Transplant Recipients: A Systematic Review.Kidney medicine · 2025Review
- Where Are All the Clinical Trials for Chronic Rejection?Transplantation · 2025Article
- Editorial: Living Well After Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Supportive care in transplantation: A patient-centered care model to better support kidney transplant candidates and recipients.World journal of transplantation · 2024Review
- The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.Biological research for nursing · 2024Review
- Associations Between Gut Microbial Features and Sickness Symptoms in Kidney Transplant Recipients.Biological research for nursing · 2024Article
- Application of Patient-Reported Outcome Measurements in Adult Tumor Clinical Trials in China: Cross-Sectional Study.Journal of medical Internet research · 2024Article
- Partnering with patients and caregivers to enrich research and care in kidney disease: values and strategies.Clinical kidney journal · 2023Review
- Embracing the Wisdom of Ancient Greece in the Era of Personalized Medicine-Uncertainty, Probabilistic Reasoning, and Democratic Consensus.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Are cultural or psychosocial factors associated with patient-reported outcomes at the conclusion of kidney transplant evaluation?Clinical transplantation · 2022Article
- A Woman's Place Is in Theatre, but Are Theatres Designed with Women in Mind? A Systematic Review of Ergonomics for Women in Surgery.Journal of clinical medicine · 2022Review
- Rationale for Surrogate Endpoints and Conditional Marketing Authorization of New Therapies for Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient-reported outcomes (PROs) that assess individuals' perceptions of life participation, medication adherence, disease symptoms, and therapy side effects are extremely relevant in the context of kidney transplantation. All PROs are potentially suitable as primary or secondary endpoints in interventional trials that aim to improve outcomes for transplant recipients. Using PRO measures (PROMs) in clinical trials facilitates assessment of the patient's perspective of their health, but few measures have been developed and evaluated in kidney transplant recipients; robust methodologies, which use validated instruments and established frameworks for reporting, are essential. Establishing a core PROM for life participation in kidney transplant recipients is a critically important need, which is being developed and validated by the Standardized Outcomes in Nephrology (SONG)-Tx Initiative. Measures involving electronic medication packaging and smart technologies are gaining traction for monitoring adherence, and could provide more robust information than questionnaires, interviews, and scales. This article summarizes information on PROs and PROMs that was included in a Broad Scientific Advice request on clinical trial design and endpoints in kidney transplantation. This request was submitted to the European Medicines Agency (EMA) by the European Society for Organ Transplantation in 2016. Following modifications, the EMA provided its recommendations in late 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.