ArticlePeerJ2022
Taxonomic and functional alterations in the salivary microbiota of children with and without severe early childhood caries (S-ECC) at the age of 3.
Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effects of dental treatment under general anesthesia on the oral health quality of life and dental fear of preschool children: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Salivary microbiome and metabolome profiles associated with dental caries in Tibetan children from high-altitude regions.Odontology · 2026Article
- The relationship between nutrition, diet, and early childhood caries: A cross-sectional study using 2009 to 2014 NHANES data.Medicine · 2026Article
- Supragingival Biomarker flora of Children With and Without Cariogenic Disease and Black Stains, Aged 3 to 6 Years.International dental journal · 2026Article
- Tagatose attenuates streptococcus mutans-induced dental caries by modulating oral microbiota and inflammatory responses in mice.BMC microbiology · 2026Article
- Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis.Journal of oral microbiology · 2026Article
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Diabetes alters the supragingival microbiome through plasma-to-saliva migration of glucose and fructose.Microbiome · 2025Article
- A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries.BMC oral health · 2024Article
- Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries.BMC oral health · 2023Article
- Correlation between caries activity and salivary microbiota in preschool children.Frontiers in cellular and infection microbiology · 2023Article
- Candida albicans enriched in orthodontic derived white spot lesions and shaped focal supragingival bacteriome.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Primary dental caries is the most prevalent oral disease among preschool children, which can cause severe damage to teeth and even affect the mental well-being of children. Various studies have demonstrated that the oral microbiome plays a pivotal role in the onset and development of dental caries. However, it remains uncertain about the key microbial markers associated with caries, owing to the limited evidence. Methods: Fifteen S-ECC children and fifteen healthy controls were selected from three-year-old children in this study. Their clinical data and oral saliva samples were collected. Shotgun sequencing was conducted to investigate the microbial differences and the relevant functions between the two groups. Results: We observed no apparent difference in oral microbial community diversity between the two groups. Still, at the genus/species levels, several characteristic genera/species such as Conclusions: Our study showed that dental caries in children were associated with the alterations in the oral microbiota at the composition and functional levels, which may potentially inspire the exploration of microbial diagnosis or therapeutic treatments.
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