Evidence map›Paper›PMID 35669867›Full record

ArticleSchizophrenia bulletin open2022

Eye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects.

David St Clair, Graeme MacLennan, Sara A Beedie, Eva Nouzová, Helen Lemmon, Dan Rujescu, Philip J Benson, Andrew McIntosh, Mintu Nath

Open access · goldAbstract read
In one paragraph

Article in Schizophrenia bulletin open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

David St ClairDivision of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Graeme MacLennanCentre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, UK.ORCID https://orcid.org/0000-0002-1039-5646
Sara A BeedieClinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK.
Eva NouzováClinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK.
Helen LemmonClinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK.
Dan RujescuDepartment of Psychiatry, Medical University of Vienna, Vienna, Austria.
Philip J BensonDepartment of Psychology, University of Aberdeen, Aberdeen, UK.
Andrew McIntoshDivision of Psychiatry, Royal Edinburgh Hospital , Edinburgh, UK.
Mintu NathMedical Statistics Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
University of Aberdeen · GBRoyal Cornhill Hospital · GBMedical University of Vienna · ATRoyal Edinburgh Hospital · GB

Funding

Chief Scientist Office HSRU1Wellcome Trust
6 · The paper itself

Abstract

Background and hypothesis: No objective tests are currently available to help diagnosis of major psychiatric disorders. This study evaluates the potential of eye movement behavior patterns to predict schizophrenia subjects compared to those with major affective disorders and control groups. Study design: Eye movements were recorded from a training set of UK subjects with schizophrenia (SCZ; Study results: Estimates of AUC in one-versus-all comparisons were: SCZ (0.85), BPAD (0.78), MDD (0.76), and CON (0.85). Estimates on part-external validation were SCZ (0.89) and CON (0.65). In all cases, there was good specificity but only moderate sensitivity. The best individual discriminators included free viewing, fixation duration, and smooth pursuit tasks. The findings appear robust to potential confounders such as age, sex, medication, or mental state at the time of testing. Conclusions: Eye movement patterns can discriminate schizophrenia from major mood disorders and control subjects with around 80% predictive accuracy.

Indexed as

affective disordersbiomarkereye movementspredictive modellingschizophrenia

Identifiers

PMID35669867
PMCPMC9155263
OpenAlexW4281260482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.