Evidence map›Paper›PMID 35669402›Full record

ArticleFrontiers in pediatrics2022

Component 1 Inhibitor Missense (Val480Met) Variant Is Associated With Gene Expression and Sepsis Development in Neonatal Lung Disease.

Enas F Elngar, Mona A Azzam, Ayman A Gobarah, Eman A Toraih, Manal S Fawzy, Nouran B AbdAllah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Enas F ElngarDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Mona A AzzamDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Ayman A GobarahDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Eman A ToraihDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA, United States.
Manal S FawzyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Nouran B AbdAllahDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Suez Canal University · EGNorthern Border University · SATulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neonatal lung disease has a multifaceted etiopathology, including an explosive inflammatory sequence in the immature lung. Complement component 1 Esterase INHibitor (C1INH) is implicated in controlling inflammation in response to infection/injury. Aim: To explore for the first time the association of the Methods: A total of 139 unrelated neonates were enrolled in this case-control study. Results: A/A genotype carriers were two times more likely to develop in newborns with lung disease under homozygote (A/A vs. G/G: OR = 2.66, 95%CI = 1.03-6.87, Conclusion: The

Indexed as

C1INHgene expressionpreterm infantReal-Time PCRsepsisSNP

Identifiers

PMID35669402
PMCPMC9163386
OpenAlexW4280553219

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.