ArticleSleep advances : a journal of the Sleep Research Society2022
Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum.
Open access · goldAbstract read
In one paragraph
Article in Sleep advances : a journal of the Sleep Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- The Role of Genetic Alterations in the Emergence of Alzheimer's Disease in Down Syndrome: A Review.The European journal of neuroscience · 2026Review
- Lifestyle intervention and cognitive outcomes in Down syndrome: a horizon 21 European Down syndrome consortium scoping review.Journal of neurodevelopmental disorders · 2026Article
- Use of anti-amyloid-β monoclonal antibodies in persons with Down syndrome Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- The Prevalence of Sleep Disorders in Populations with Glymphatic Dysfunction: A Systematic Review and Meta-Analysis.Biology · 2026Review
- Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Review
- Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory.Hippocampus · 2025Article
- Resistance and resilience to Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome.Cell reports · 2024Article
- Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome.Scientific reports · 2024Article
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Possible genetic cross-talk between Down syndrome and obstructive sleep apnea revealed by transcriptomic analysis.Sleep & breathing = Schlaf & Atmung · 2023Article
- Comprehensive and stratified meta-analysis of diffusion tensor image analysis along the perivascular space in Alzheimer's disease: Linking glymphatic dysfunction with cognitive decline and amyloid pathology.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 6 institutions in 1 country.
Patrick LaoGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID https://orcid.org/0000-0003-2243-3547
Molly E ZimmermanDepartment of Psychology, Fordham University, Bronx, NY 10458, USA.ORCID https://orcid.org/0000-0002-8071-5369
Sigan L HartleyWaisman Center, University of Wisconsin-Madison, Madison, WI, 53706, USA.
José GutierrezDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID https://orcid.org/0000-0002-2175-8078
David KeatorDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Kay C IgweDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Krystal K LaingDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Dejania Cotton-SamuelDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Mithra SathishkumarDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Fahmida MoniDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Howard AndrewsGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Sharon Krinsky-McHaleGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Elizabeth HeadDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Joseph H LeeGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Florence LaiDepartment of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA.
Michael A YassaDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.
H Diana RosasDepartment of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA.
Wayne SilvermanDepartment of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
Ira T LottDepartment of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
Nicole SchupfGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Adam M BrickmanGertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Columbia University · USUniversity of California, Irvine · USHarvard University · USNew York State Office for People With Developmental Disabilities · USFordham University · USUniversity of Wisconsin–Madison · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MProject 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTIAN, BRADLEY T, HANDEN, BENJAMIN L · 2020 to 2025
$103.7MClinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MThe Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Craig E Stark · 2020 to 2026
$27.9MBiomarkers of Alzheimer's Disease in Adults with Down SyndromeU01AG051412 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOTT, IRA T., SCHUPF, NICOLE · 2015 to 2019
$26.3MCerebrovascular contributions to Alzheimer's disease in adults with Down SyndromeRF1AG079519 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, HEAD, ELIZABETH · 2022 to 2022
$3.1MUnderstanding the mechanisms linking small vessel cerebrovascular disease and Alzheimer's disease pathophysiology with neurodegeneration and cognition during midlifeK99AG065506 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAO, PATRICK JORDAN · 2020 to 2021
$260kNCATS NIH HHS UL1 TR001873NIA NIH HHS K99 AG065506NIA NIH HHS P30 AG066519NIA NIH HHS RF1 AG079519NIA NIH HHS U01 AG051412NIA NIH HHS U19 AG068054NIA NIH HHS U24 AG021886
Abstract
We determined the extent to which obstructive sleep apnea (OSA) is associated with increased cerebrovascular disease and amyloid burden, and the relation of the two processes across clinical Alzheimer's disease (AD) diagnostic groups in adults with Down syndrome (DS). Adults with DS from the Biomarkers of Alzheimer's Disease in Down Syndrome (ADDS) study were included given available research MRI (
Indexed as
Alzheimer’s diseaseCerebrovascular diseaseDown syndromeObstructive sleep apnea
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.