ReviewFrontiers in surgery2022
Perioperative Systemic Inflammation in Lung Cancer Surgery.
Review in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Preoperative inflammation-based biomarkers and postoperative pulmonary complications after lung resection for lung cancer: a systematic review with selective exploratory quantitative synthesis.Frontiers in surgery · 2026Pooled it
- Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Lidocaine as a promising adjunct to reduce complications after lung resection.Journal of thoracic disease · 2026Article
- Preoperative Inflammatory Ratios and Severe Intraoperative Hypoxemia During One-Lung Ventilation: A Prospective Observational Study.Life (Basel, Switzerland) · 2026Article
- Machine learning prediction model for early postoperative hypoalbuminemia after pulmonary surgery: a retrospective case-matched comparative study.Journal of thoracic disease · 2026Article
- Association between Inpatient Moderate-to-vigorous Physical Activity and Functional Recovery following Lung Resection for Neoplastic Lung Diseases.Progress in rehabilitation medicine · 2026Article
- Inflammatory biomarkers and 30-day thoracic outcomes after surgical versus non-surgical management of spontaneous pneumothorax: a retrospective cohort study.Frontiers in medicine · 2026Article
- The future of lung cancer surgery lies between innovations: synergy across the perioperative ERATS pathway.Frontiers in oncology · 2026Review
- A score prediction model for predicting the heterogeneity symptom trajectories among lung cancer patients during perioperative period: a longitudinal observational study.Annals of medicine · 2025Observational
- Association of inflammatory markers and surgical intervention with postoperative pneumonia in patients with femoral intertrochanteric fracture: A propensity score-matched cohort study.Journal of orthopaedics · 2025Article
- Risk factors for pulmonary infection after thoracoscopic radical resection of lung cancer in elderly patients with diabetes mellitus.World journal of diabetes · 2025Article
- A comparative study of the effects of spontaneous ventilation versus one-lung mechanical ventilation on ipsilateral lung injury during thoracic surgery: an empirical analysis based on a rat model.Journal of thoracic disease · 2025Article
- Impact of spontaneous ventilation with intubation on perioperative results in uniportal VATS lobectomy compared to general anaesthesia using a double-lumen tube.Journal of thoracic disease · 2025Article
- A Prognostic Nomogram Combining Postoperative SII and PIV Improves Long-Term Survival Prediction in NSCLC.Journal of inflammation research · 2025Article
- Impact of preoperative inflammatory biomarkers on postoperative pneumonia and one-month pulmonary imaging changes after surgery for non-small cell lung cancer.Frontiers in oncology · 2025Article
- Advances in the use of non-intubated spontaneous-ventilation video-assisted thoracoscopic surgery.Frontiers in surgery · 2025Review
- Does perioperative electroacupuncture reduce the incidence of atrial fibrillation after lung cancer surgery? A randomized, controlled, assessor-blinded clinical trial.Frontiers in medicine · 2025Article
- Impact of Intraoperative Dexamethasone on Postoperative Complications and Long-Term Survival in Patients with Non-Small Cell Lung Cancer: A retrospective Propensity Score-Matched Study.International journal of general medicine · 2025Article
- Nomogram for Predicting Postoperative Cardiopulmonary Complications in Non-Small Cell Lung Cancer Based on Systemic Inflammatory Markers: A Retrospective Study.Journal of inflammation research · 2025Article
- Longitudinal monitoring of autoantibody dynamics in patients with early-stage non-small-cell lung cancer undergoing surgery.Open life sciences · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammation (SI) is a response of the immune system to infectious or non-infectious injuries that defends the body homeostasis. Every surgical intervention triggers SI, the level of which depends on the extent of damage caused by the surgery. During the first few hours after the damage, the innate or natural immunity, involving neutrophils, macrophages, and natural killer cells, plays a main role in the defense mechanism, but thereafter the adaptive immune response ensues. The number of leukocytes is elevated, the levels of lymphocytes and natural killer cells are reduced, and the cytokines released after surgery correlate with surgical damage. Minimally invasive thoracic surgery procedures induce less inflammatory response and reduce the immune defense in patients to a more moderate level compared with the open surgery procedures; this immunosuppression can be further diminished in spontaneous ventilation cases. The normal functioning of the immune defense is important in controlling the perioperative circulatory tumor cells. Moreover, elevated levels of inflammatory cytokines before immune therapy have a negative impact on the response, and significantly shorten the progression-free survival. Clinically, the lower are the levels of cytokines released during lung surgery, the lesser is the postoperative morbidity, especially pneumonia and wound infection. The return to normal levels of lymphocytes and cytokines occurs faster after spontaneous ventilation surgery. The use of locoregional anesthesia can also reduce SI. Herein, we review the current knowledge on the effects of different operative factors on postoperative SI and defense mechanism in lung cancer surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.