Evidence map›Paper›PMID 35669236›Full record

ArticleNAR genomics and bioinformatics2022

Systematic evaluation of parameters in RNA bisulfite sequencing data generation and analysis.

Zachary Johnson, Xiguang Xu, Christina Pacholec, Hehuang Xie

Open access · goldAbstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Most m5C Modifications in Mammalian mRNAs are Nonadaptive.Molecular biology and evolution · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Dynamics of RNA mGenomics · 2023
    Article
  11. Article
  12. Folate regulates RNA mBMC biology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zachary JohnsonEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Xiguang XuEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Christina PacholecEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Hehuang XieEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.ORCID https://orcid.org/0000-0001-5739-1653
Virginia–Maryland College of Veterinary Medicine · USVirginia Tech · US

Funding

Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
The epigenetic role of EGR1 during postnatal brain development and in neuronal activityR01NS094574 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI XIE, HEHUANG · 2016 to 2020
$1.7M
Exploring epigenetic regulation of memory extinctionR21MH120498 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAROME, TIMOTHY JOSEPH, XIE, HEHUANG · 2020 to 2020
$419k
NIEHS NIH HHS R01 ES031521NIMH NIH HHS R21 MH120498NINDS NIH HHS R01 NS094574
6 · The paper itself

Abstract

The presence of 5-methylcytosine (m

Identifiers

PMID35669236
PMCPMC9164272
OpenAlexW4281758364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.