ArticlePractical laboratory medicine2022
The effect of acute changes in glomerular filtration rate on common biochemical tests.
Article in Practical laboratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Acute Kidney Injury and High-Sensitivity Cardiac Troponin T Levels in the Emergency Department.JAMA network open · 2024Article
- Advances in laboratory detection of acute kidney injury.Practical laboratory medicine · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To characterise the effect of acute kidney injury on the concentration of common biochemical analytes. Design: and methods: Pairs of serum or plasma samples from the same patients routinely submitted to the laboratory were subject to further analysis based on changes in serum creatinine within 72 h. Samples collected from patients on dialysis were excluded. Samples were measured for 28 biochemical analytes including electrolytes, liver function tests, iron studies, creatine kinase, amylase, lipase, parathyroid hormone, troponin T and troponin I, B-natriuretic peptide and NT pro B-natriuretic peptide. Results: 148 sample pairs were included with 99 having a rise in serum creatinine >50%, 18 with a fall of >50% and 31 with smaller changes. Acute changes in renal function were associated with changes in the concentration of several analytes, with the changes of the greatest magnitude observed in urea, phosphate, urate, parathyroid hormone, troponin T, BNP and NT-ProBNP. The remaining analytes did not show significant changes with changes in renal function. Conclusion: Acute changes in renal function are associated with significant changes in concentration of some serum/plasma biochemical analytes but not others. Expected changes in analyte concentration must be considered in the setting of acute kidney injury to avoid misinterpretation of blood test results.
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