ArticleFrontiers in nutrition2022
Application of Ultrasound as Clean Technology for Extraction of Specialized Metabolites From Stinging Nettle (
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Natural Antimicrobial Activity of Nettle (Food science & nutrition · 2026Article
- Improved Hybrid Percolation-Ultrasound Extraction of Bioactive Compounds and Their Application as Nettle and Sage-Derived Biostimulants in Tomato and Pepper Crops.Foods (Basel, Switzerland) · 2025Article
- Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014-2023).Chemistry & biodiversity · 2025Review
- An Overview on Nettle Studies, Compounds, Processing and the Relation with Circular Bioeconomy.Plants (Basel, Switzerland) · 2024Review
- Acoustic cavitation for agri-food applications: Mechanism of action, design of new systems, challenges and strategies for scale-up.Ultrasonics sonochemistry · 2024Review
- How to Increase the Nutritional Quality of Stinging Nettle Through Controlled Plant NutritionFood technology and biotechnology · 2023Article
- Comparative Analysis of Volatile Compounds from Four Radish Microgreen Cultivars Based on Ultrasonic Cell Disruption and HS-SPME/GC-MS.International journal of molecular sciences · 2023Article
- Ultrasonic-Assisted Extraction and Antioxidant Potential of Valuable Protein fromLife (Basel, Switzerland) · 2022Article
- Ultrasound assisted cyanotoxin extraction for nematode inhibition in soil.Ultrasonics sonochemistry · 2022Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nettle is a highly valued medicinal plant that is still largely neglected, both in terms of nutrition and use for pharmacological purposes. Tinctures, i.e., alcoholic extracts, are becoming increasingly popular nettle products, mainly because they allow better availability of phytochemicals and their stability over a longer period of time. The production of alcoholic extracts is a chemically demanding process that is still usually carried out using conventional techniques, which have numerous drawbacks. The use of green technologies such as ultrasound-assisted extraction (UAE), which is characterized by high efficiency of phytochemical extraction, shorter treatment time, and a much lower environmental footprint, is a suitable and sustainable solution. Therefore, the aim of this study is to determine the influence of the extraction method, conventional and ultrasound (by varying two ultrasound equipment systems), time and ethanol concentration on the extraction of specialized metabolites from nettle powder. Ultrasonic extraction using a probe system significantly contributed to increase the ascorbic acid yield, polyphenolic compounds, and antioxidant capacity of nettle extracts compared to conventional extraction. In addition, when a probe system was used during UAE, significantly less time was required for isolation of individual specialized metabolites compared to ultrasonic extraction in the bath. Ethanol concentration (50 and 80% v/v) also proved to be an important factor in the efficiency of extraction of specialized metabolites, with 80% ethanol being more effective for the isolation of ascorbic acid and pigment compounds (chlorophyll and carotenoids), while 50% v/v for the extraction of polyphenolic compounds. It can be concluded that extraction with the ultrasonic probe system is much more efficient in obtaining higher yields of specialized metabolites from nettle powder in a shorter time (average process duration 5-10 min) both compared to UAE in the bath and classical extraction. However, optimization of the key factors of time, solvent type, and ultrasonic power is necessary to maintain the nutritional quality of the nettle extract in order to obtain a final product with a high specialized metabolites content, antioxidant capacity, and functional value. The future application of alcoholic nettle extracts is based on the fact that these products have significant potential as functional foods and pharmacological preparations for the treatment of a number of but also to strengthen the immune system, mainly due to the rich nutritional composition and high content of various specialized metabolites. The prepared extracts can be safely taken orally by diluting the tinctures with water immediately before ingestion.
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