Evidence map›Paper›PMID 35668923›Full record

ReviewRegenerative biomaterials2022

Rational design of hydrogels for immunomodulation.

Wenhuan Bu, Yuanhao Wu, Amir M Ghaemmaghami, Hongchen Sun, Alvaro Mata

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Wenhuan BuLiaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology, China Medical University, No. 117, Nanjing North Street, Heping District, Shenyang 110001, China.ORCID https://orcid.org/0000-0003-1760-1606
Yuanhao WuSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Amir M GhaemmaghamiDivision of Immunology, School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Hongchen SunLiaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology, China Medical University, No. 117, Nanjing North Street, Heping District, Shenyang 110001, China.
Alvaro MataSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
University of Nottingham · GBChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development, repair and regeneration. Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes, short half-life and lack of targeting ability. Encapsulating or binding these biologics within biomaterials is an effective way to address these problems. Hydrogels are promising immunomodulatory materials because of their prominent biocompatibility, tuneability and versatility. However, to take advantage of these opportunities and optimize material performance, it is important to more specifically elucidate, and leverage on, how hydrogels affect and control the immune response. Here, we summarize how key physical and chemical properties of hydrogels affect the immune response. We first provide an overview of underlying steps of the host immune response upon exposure to biomaterials. Then, we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through (i) physical properties including dimensionality, stiffness, porosity and topography; (ii) chemical properties including wettability, electric property and molecular presentation;and (iii) the delivery of bioactive molecules via chemical or physical cues. Thus, this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response.

Indexed as

chemical propertieshydrogelsimmunomodulationphysical properties

Identifiers

PMID35668923
PMCPMC9160883
OpenAlexW4212927932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.