Evidence map›Paper›PMID 35668819›Full record

ArticleAdvanced materials technologies2022

Vitrification and Rewarming of Magnetic Nanoparticle-Loaded Rat Hearts.

Zhe Gao, Baterdene Namsrai, Zonghu Han, Purva Joshi, Joseph Sushil Rao, Vasanth Ravikumar, Anirudh Sharma, Hattie L Ring, Djaudat Idiyatullin, Elliott C Magnuson and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials technologies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
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  5. Reconstitution of thymopoiesis via implantation of cryopreserved cultured thymus tissue into athymic recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  6. Advanced Rewarming Technologies for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Improved Rat Heart Preservation Using High-Pressure Gaseous Perfusion with Oxygen-Xenon Mixture.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  15. Article
  16. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Zhe GaoDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
Baterdene NamsraiDepartment of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Zonghu HanDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
Purva JoshiDepartment of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.
Joseph Sushil RaoDepartment of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Vasanth RavikumarDepartment of Biomedical Engineering, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA.
Anirudh SharmaDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
Hattie L RingCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street S.E. Minneapolis, Minneapolis, MN 55455, USA.
Djaudat IdiyatullinCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street S.E. Minneapolis, Minneapolis, MN 55455, USA.
Elliott C MagnusonDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
Paul A IaizzoDepartment of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Elena G TolkachevaDepartment of Biomedical Engineering, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA.
Michael GarwoodCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street S.E. Minneapolis, Minneapolis, MN 55455, USA.
Yoed RabinDepartment of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.
Michael EtheridgeDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
Erik B FingerDepartment of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
John C BischofDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE., Minneapolis, MN 55455, USA.
University of Minnesota · USCarnegie Mellon University · US

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
Breakthrough Tissue and Organ Preservation and Transplantation Using Scaled-Up Nanowarming TechnologyR01HL135046 · NHLBI · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2017 to 2020
$2.6M
Engineering optimization and scaling enables high quality pancreatic islet cryopreservation for banking and transplantR01DK131209 · NIDDK · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2021 to 2024
$2.3M
NHLBI NIH HHS R01 HL135046NIDDK NIH HHS R01 DK117425NIDDK NIH HHS R01 DK131209
6 · The paper itself

Abstract

To extend the preservation of donor hearts beyond the current 4-6 h, this paper explores heart cryopreservation by vitrification-cryogenic storage in a glass-like state. While organ vitrification is made possible by using cryoprotective agents (CPA) that inhibit ice during cooling, failure occurs during convective rewarming due to slow and non-uniform rewarming which causes ice crystallization and/or cracking. Here an alternative, "nanowarming", which uses silica-coated iron oxide nanoparticles (sIONPs) perfusion loaded through the vasculature is explored, that allows a radiofrequency coil to rewarm the organ quickly and uniformly to avoid convective failures. Nanowarming has been applied to cells and tissues, and a proof of principle study suggests it is possible in the heart, but proper physical and biological characterization especially in organs is still lacking. Here, using a rat heart model, controlled machine perfusion loading and unloading of CPA and sIONPs, cooling to a vitrified state, and fast and uniform nanowarming without crystallization or cracking is demonstrated. Further, nanowarmed hearts maintain histologic appearance and endothelial integrity superior to convective rewarming and indistinguishable from CPA load/unload control hearts while showing some promising organ-level (electrical) functional activity. This work demonstrates physically successful heart vitrification and nanowarming and that biological outcomes can be expected to improve by reducing or eliminating CPA toxicity during loading and unloading.

Indexed as

cryopreservationheartiron oxide nanoparticleradio frequency warmingvitrification

Identifiers

PMID35668819
PMCPMC9164386
OpenAlexW3202935785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.