Evidence map›Paper›PMID 35668488›Full record

ArticleHead & face medicine2022

Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model.

Joo-Hyung Yoon, Dae-Won Kim, Suk Keun Lee, Seong-Gon Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & face medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joo-Hyung YoonDepartment of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, 25457, Gangneung, Gangwondo, Republic of Korea.
Dae-Won KimDepartment of Oral Biochemistry, College of Dentistry, Gangneung-Wonju National University, 28644, Gangneung, Korea.
Suk Keun LeeInstitution of Hydrogen Magnetic Reaction Gene Regulation, 34140, Daejeon, Korea.
Seong-Gon KimDepartment of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, 25457, Gangneung, Gangwondo, Republic of Korea. kimsg@gwnu.ac.kr.ORCID http://orcid.org/0000-0001-5088-2732
Gangneung–Wonju National University · KR

Funding

Rural Development Administration PJ01562601
6 · The paper itself

Abstract

background4-Hexylresorcinol (4HR) is a food additive and class I histone deacetylase inhibitor. In this study, we examined the effects of 4HR administration on the submandibular gland in a growing rat model.

methodsFour-week-old rats were used in this study. The experimental group (nine males and eight females) received 12.8 mg/kg of 4HR weekly for 12 weeks. Ten rats (five males and five females) were used as controls. The submandibular glands of rats were collected 12 weeks after the first administration of 4HR. The weight of the glands was measured. Histological analysis, immunoprecipitation-high-performance liquid chromatography (IP-HPLC), and western blotting were performed.

resultsThe weights of the rat submandibular glands were higher in the experimental groups than in the control group, especially in male rats (P < 0.05). The vascular endothelial growth factor (VEGF) and testosterone in the submandibular glands were more highly expressed in 4HR-treated male rats than in untreated rats, as detected by both western blotting and immunohistochemistry. The IP-HPLC results demonstrated that the expression levels of Ki67, epidermal growth factor, and testosterone in the submandibular glands were higher in 4HR-treated male rats than in untreated rats.

conclusionsThis study demonstrated that the systemic administration of 4HR increased the weight of submandibular glands in male rats. In addition, the testosterone and VEGF expression levels in the submandibular glands increased owing to 4HR administration.

Indexed as

HexylresorcinolAnimalsBlotting, WesternFemaleHumansMaleRatsSubmandibular GlandTestosteroneVascular Endothelial Growth Factor AHexylresorcinolTestosteroneVascular Endothelial Growth Factor A4-hexylresorcinolAngiogenesisSalivary glandTestosterone

Identifiers

PMID35668488
PMCPMC9172157
OpenAlexW4281710461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.