Evidence map›Paper›PMID 35668345›Full record

ReviewApplied health economics and health policy2022

Supply-Side Cost-Effectiveness Thresholds: Questions for Evidence-Based Policy.

Chris Sampson, Bernarda Zamora, Sam Watson, John Cairns, Kalipso Chalkidou, Patricia Cubi-Molla, Nancy Devlin, Borja García-Lorenzo, Dyfrig A Hughes, Ashley A Leech and 1 more

Abstract readReview
In one paragraph

Review in Applied health economics and health policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the PREFERABLE-EFFECT Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
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  13. A Model-Based Estimate of the Cost-Effectiveness Threshold in Germany.Applied health economics and health policy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chris SampsonOffice of Health Economics, London, UK. csampson@ohe.org.ORCID 0000-0001-9470-2369
Bernarda ZamoraImperial College London, London, UK.
Sam WatsonUniversity of Birmingham, Birmingham, UK.
John CairnsLondon School of Hygiene and Tropical Medicine, London, UK.
Kalipso ChalkidouImperial College London, London, UK.
Patricia Cubi-MollaOffice of Health Economics, London, UK.
Nancy DevlinUniversity of Melbourne, Melbourne, Australia.
Borja García-LorenzoKronikgune Institute for Health Services Research, Basque Country, Spain.
Dyfrig A HughesCentre for Health Economics and Medicines Evaluation, Bangor University, Bangor, UK.
Ashley A LeechVanderbilt University, Nashville, USA.
Adrian TowseOffice of Health Economics, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing interest in cost-effectiveness thresholds as a tool to inform resource allocation decisions in health care. Studies from several countries have sought to estimate health system opportunity costs, which supply-side cost-effectiveness thresholds are intended to represent. In this paper, we consider the role of empirical estimates of supply-side thresholds in policy-making. Recent studies estimate the cost per unit of health based on average displacement or outcome elasticity. We distinguish the types of point estimates reported in empirical work, including marginal productivity, average displacement, and outcome elasticity. Using this classification, we summarise the limitations of current approaches to threshold estimation in terms of theory, methods, and data. We highlight the questions that arise from alternative interpretations of thresholds and provide recommendations to policymakers seeking to use a supply-side threshold where the evidence base is emerging or incomplete. We recommend that: (1) policymakers must clearly define the scope of the application of a threshold, and the theoretical basis for empirical estimates should be consistent with that scope; (2) a process for the assessment of new evidence and for determining changes in the threshold to be applied in policy-making should be created; (3) decision-making processes should retain flexibility in the application of a threshold; and (4) policymakers should provide support for decision-makers relating to the use of thresholds and the implementation of decisions stemming from their application.

Indexed as

Delivery of Health CarePolicy MakingCost-Benefit AnalysisHumansPolicyQuality-Adjusted Life Years

Identifiers

PMID35668345
PMCPMC9385803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.