ReviewNature reviews. Nephrology2022
Patient-centred clinical trial design.
Review in Nature reviews. Nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The role of TNF signaling pathway in post-stroke cognitive impairment: a systematic review.Annals of medicine · 2025Pooled it
- Bridging the gap between evidence and clinical practice for migraine headaches: a systematic review (2019-2024).The journal of headache and pain · 2025Pooled it
- Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review.BMJ open · 2025Pooled it
- Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis.Neurology · 2024Pooled it
- Lianxia Xiaopi Granules for Treatment of Functional Dyspepsia: A Multicenter, Randomized, Double-Blind and Placebo-Controlled Trial.Chinese journal of integrative medicine · 2026Trial
- Renaclic for Chronic Kidney Disease Self-Management: Formative User-Centered Co-Design Study.JMIR formative research · 2026Article
- Article
- A combined progressive muscle relaxation and walking intervention for adults with end-stage kidney disease receiving hemodialysis (Contemporary clinical trials communications · 2026Article
- Efficacy of cilastatin sodium in a translational large animal crush syndrome model.Communications medicine · 2026Article
- Article
- The Current Landscape of Clinical Trials.Journal of clinical medicine · 2025Article
- Interventions to Improve Life Participation in Kidney Transplant Recipients: A Systematic Review.Kidney medicine · 2025Review
- Patient-reported outcome measures for life participation in patients with chronic kidney disease: a systematic review.Clinical kidney journal · 2025Article
- A scoping review of patient and public involvement in empirical stroke research.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Patient and Public Perceptions in Canada About Decentralized and Hybrid Clinical Trials: "It's About Time we Bring Trials to People".Therapeutic innovation & regulatory science · 2024Article
- Approaches and experiences implementing remote, electronic consent at the Leeds Clinical Trials Research Unit.Trials · 2024Article
- How can we support research participants who stop taking part? Communications guidance developed through public-researcher collaboration.Research involvement and engagement · 2024Article
- Delivering Digital Health Solutions that Patients Need: A Call to Action.Therapeutic innovation & regulatory science · 2024Article
- Technology and Human Support Systems in Decentralized Studies: A Participant-Centered Case Study in Cystic Fibrosis.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Molecular and modular intricacies of precision oncology.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient involvement in clinical trial design can facilitate the recruitment and retention of participants as well as potentially increase the uptake of the tested intervention and the impact of the findings on patient outcomes. Despite these benefits, patients still have very limited involvement in designing and conducting trials in nephrology. Many trials do not address research questions and outcomes that are important to patients, including patient-reported outcomes that reflect how patients feel and function. This limitation can undermine the relevance, reliability and value of trial-based evidence for decision-making in clinical practice and health policy. However, efforts to involve patients with kidney disease are increasing across all stages of the trial process from priority setting, to study design (including selection of outcomes and approaches to improve participant recruitment and retention) and dissemination and implementation of the findings. Harnessing the patient voice in designing trials can ensure that efforts and resources are directed towards patient-centred trials that address the needs, concerns and priorities of patients living with kidney disease with the aim of achieving transformative improvements in care and outcomes.
Indexed as
Identifiers
35668231What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.