ArticleMolecular psychiatry2022
Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol.
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Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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25 citing papers in PubMed, 32 citations in OpenAlex.
- Moderate prenatal alcohol exposure differentially alters acute ethanol sensitivity of GABAergic transmission in CRFR1- and CRFR1+ CeM Neurons.Addiction neuroscience · 2026Article
- The central amygdala corticotropin releasing factor system regulates anxiety-like behavior in an age- and sex- dependent manner in rats.Addiction neuroscience · 2026Article
- Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence.bioRxiv : the preprint server for biology · 2026Article
- Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation.ACS chemical neuroscience · 2026Article
- Activation of GLP-1R ameliorates alcohol withdrawal induced anxiety-like behavior by regulating neuronal mitochondrial quality control.Frontiers in pharmacology · 2026Article
- Chronic Alcohol Drinking Impairs Recognition Memory And Insulin-Associated Genes In The Medial Prefrontal Cortex.Molecular neurobiology · 2025Article
- Selectively counteracting cerebellar adaptations to chronic alcohol exposure reduces acute alcohol withdrawal severity in C57BL6/N mice.Neuropharmacology · 2025Article
- Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function.Immunity · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Motivating Effects of Negative-hedonic Valence Encoded in Engrams.Research square · 2025Article
- Chronic ethanol exposure produces long-lasting, subregion-specific physiological adaptations in RMTg-projecting mPFC neurons.Neuropharmacology · 2024Article
- Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats.Neurobiology of disease · 2024Article
- Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure.Neurobiology of stress · 2024Article
- Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice.Molecular psychiatry · 2024Article
- Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence.Neurobiology of disease · 2024Article
- Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder.Addiction neuroscience · 2023Article
- Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol-evoked neuropathic pain.British journal of pharmacology · 2023Article
- Sex-dependent factors of alcohol and neuroimmune mechanisms.Neurobiology of stress · 2023Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Reesha R PatelThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Sarah A WolfeThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Vittoria BorgonettiThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Pauravi J GandhiThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Larry RodriguezThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-9591-5005
Angela E SnyderThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-6501-4548
Shannon D'AmbrosioThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Michal BajoThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Alain DomissyThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-7376-8294
Steven HeadThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Candice ContetThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-4459-9540
R Dayne MayfieldDepartment of Neuroscience, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID http://orcid.org/0000-0002-8045-1789
Amanda J RobertsThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Marisa RobertoThe Scripps Research Institute, 10550N. Torrey Pines Rd, La Jolla, CA, 92037, USA. mroberto@scripps.edu.ORCID http://orcid.org/0000-0003-0729-3961
Scripps Research Institute · USThe University of Texas at Austin · US
Funding
Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3MNeurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4MElectrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6MGENE EXPRESSION IN THE HUMAN ALCOHOLIC BRAINR01AA012404 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI MAYFIELD, ROY DAYNE · 2000 to 2025
$10.7MNext Generation Sequencing of Human Alcoholic BrainU01AA020926 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Roy DAYNE MAYFIELD · 2011 to 2026
$6.7MSYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI SIGGINS, GEORGE ROBERT · 1985 to 2002
$5.1MRegulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6MNeuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9MGene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7MActivation of the parasubthalamic nucleus in alcohol dependenceR01AA026685 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Jeffery Lee Dunning · 2018 to 2026
$3.0MNeuroimmune mechanisms in stress and alcohol comorbidityR01AA027700 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2019 to 2023
$2.4MSynaptic Mechanisms underlying sex-differences in alcohol use disorderR01AA029841 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2022 to 2026
$2.0MNIAAA NIH HHS F32 AA026765NIAAA NIH HHS K99 AA029180NIAAA NIH HHS P50 AA006420NIAAA NIH HHS R01 AA012404NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA026685NIAAA NIH HHS R01 AA027700NIAAA NIH HHS R01 AA029841NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIAAA NIH HHS U01 AA013498NIAAA NIH HHS U01 AA020926
Abstract
Prefrontal circuits are thought to underlie aberrant emotion contributing to relapse in abstinence; however, the discrete cell-types and mechanisms remain largely unknown. Corticotropin-releasing factor and its cognate type-1 receptor, a prominent brain stress system, is implicated in anxiety and alcohol use disorder (AUD). Here, we tested the hypothesis that medial prefrontal cortex CRF1-expressing (mPFC
Indexed as
AlcoholismSubstance Withdrawal SyndromeAnxietyCorticotropin-Releasing HormoneEthanolHumansNeuronsReceptors, Corticotropin-Releasing HormoneCorticotropin-Releasing HormoneEthanolReceptors, Corticotropin-Releasing Hormone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.