Evidence map›Paper›PMID 35668147›Full record

ArticleNature materials2022

Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts.

Barbara Spagnolo, Antonio Balena, Rui T Peixoto, Marco Pisanello, Leonardo Sileo, Marco Bianco, Alessandro Rizzo, Filippo Pisano, Antonio Qualtieri, Dario Domenico Lofrumento and 5 more

Abstract read
In one paragraph

Article in Nature materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Barbara Spagnolo *Istituto Italiano di Tecnologia, CBN, Lecce, Italy. barbara.spagnolo@iit.it.ORCID http://orcid.org/0000-0001-7377-2819
Antonio Balena *Istituto Italiano di Tecnologia, CBN, Lecce, Italy. antonio.balena@iit.it.ORCID http://orcid.org/0000-0003-4314-4314
Rui T Peixoto *Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Marco Pisanello *Istituto Italiano di Tecnologia, CBN, Lecce, Italy.
Leonardo SileoIstituto Italiano di Tecnologia, CBN, Lecce, Italy.
Marco BiancoIstituto Italiano di Tecnologia, CBN, Lecce, Italy.
Alessandro RizzoIstituto Italiano di Tecnologia, CBN, Lecce, Italy.
Filippo PisanoIstituto Italiano di Tecnologia, CBN, Lecce, Italy.
Antonio QualtieriIstituto Italiano di Tecnologia, CBN, Lecce, Italy.ORCID http://orcid.org/0000-0002-2207-8111
Dario Domenico LofrumentoDiSTeBA - Department of Biological and Environmental Sciences and Technologies, Università del Salento, Lecce, Italy.ORCID http://orcid.org/0000-0002-0106-3615
Francesco De NuccioDiSTeBA - Department of Biological and Environmental Sciences and Technologies, Università del Salento, Lecce, Italy.
John A AssadHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0095-9177
Massimo De VittorioIstituto Italiano di Tecnologia, CBN, Lecce, Italy. massimo.devittorio@iit.it.ORCID http://orcid.org/0000-0003-1601-6392
Ferruccio PisanelloIstituto Italiano di Tecnologia, CBN, Lecce, Italy. ferruccio.pisanello@iit.it.ORCID http://orcid.org/0000-0002-1489-7758

Funding

Controlling the spatial extent of light-based monitoring and manipulation of neural activity in vivoUF1NS108177 · NINDS · HARVARD MEDICAL SCHOOL · PI ASSAD, JOHN, DEVITTORIO, MASSIMO · 2018 to 2018
$1.9M
Novel optrodes for large-scale electrophysiology and site-specific stimulationU01NS094190 · NINDS · HARVARD MEDICAL SCHOOL · PI ASSAD, JOHN, BERDONDINI, LUCA · 2015 to 2017
$1.6M
European Research Council 677683European Research Council 692943European Research Council 966674Howard Hughes Medical InstituteNINDS NIH HHS U01 NS094190NINDS NIH HHS UF1 NS108177
6 · The paper itself

Abstract

Deciphering the neural patterns underlying brain functions is essential to understanding how neurons are organized into networks. This deciphering has been greatly facilitated by optogenetics and its combination with optoelectronic devices to control neural activity with millisecond temporal resolution and cell type specificity. However, targeting small brain volumes causes photoelectric artefacts, in particular when light emission and recording sites are close to each other. We take advantage of the photonic properties of tapered fibres to develop integrated 'fibertrodes' able to optically activate small brain volumes with abated photoelectric noise. Electrodes are positioned very close to light emitting points by non-planar microfabrication, with angled light emission allowing the simultaneous optogenetic manipulation and electrical read-out of one to three neurons, with no photoelectric artefacts, in vivo. The unconventional implementation of two-photon polymerization on the curved taper edge enables the fabrication of recoding sites all around the implant, making fibertrodes a promising complement to planar microimplants.

Indexed as

ArtifactsOptogeneticsBrainElectrodesNeurons

Identifiers

PMID35668147
PMCPMC7612923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.