SynthesisNature communications2022
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
14.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.Genome medicine · 2024Pooled it
- Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits.American journal of human genetics · 2024Pooled it
- Multi-omic analyses of the same sample using metabolomics, lipidomics, proteomics, phosphoproteomics, and glycoproteomics.Chemical communications (Cambridge, England) · 2026Article
- Pleiotropy and eQTL analysis identify shared genetic architecture of lipid traits in African-ancestry populations.Human molecular genetics · 2026Article
- Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.Brain : a journal of neurology · 2026Article
- Article
- Functional genomic analysis reveals HAVCR1 as the key regulator of 5q33.3 locus linked to hyperlipidemia.HGG advances · 2026Article
- Article
- A lipidomics roadmap: from basic research to societal challenges.Nature communications · 2026Review
- Mendelian Randomization Identifies Lipidomic Signatures of Depression Risk That Are Partly Reflected in Cortisol-Induced Membrane Remodeling and Modulated by St. John's Wort Extract (Ze 117).International journal of molecular sciences · 2026Article
- Assessing current capabilities for incorporating lipidomics in multiomics data integration.Briefings in bioinformatics · 2026Review
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and Mendelian randomization.PLoS medicine · 2026Observational
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic-dysfunction-associated steatotic liver diseases.Molecular therapy. Nucleic acids · 2026Article
- Leveraging large-scale biobanks for therapeutic target discovery.HGG advances · 2026Article
- Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population.Frontiers in cardiovascular medicine · 2026Article
- Article
- Association between blood lipids, BMI and gestational diabetes mellitus in early pregnancy: a clinical study and Mendelian randomization.Frontiers in endocrinology · 2026Article
- Polygenic modeling of genetic effects on both phenotypic mean and variance: distributional regression for BMI, blood and urine biomarkers in the UK Biobank.Frontiers in bioinformatics · 2026Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 14 institutions in 4 countries.
Gemma Cadby *School of Population and Global Health, University of Western Australia, Crawley, WA, Australia.ORCID 0000-0001-7317-6531
Corey Giles *Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0002-6050-1259
Phillip E MeltonSchool of Population and Global Health, University of Western Australia, Crawley, WA, Australia.ORCID 0000-0003-4026-2964
Kevin HuynhBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0001-6170-2207
Natalie A MellettBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Thy DuongBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0002-2521-078X
Anh NguyenBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Michelle CinelBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Alex SmithBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Gavriel OlshanskyBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0002-5122-5547
Tingting WangBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Marta BrozynskaBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Mike InouyeBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Nina S McCarthySchool of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.
Amir AriffSchool of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
Joseph HungSchool of Medicine, The University of Western Australia, Crawley, WA, Australia.ORCID 0000-0002-4468-6097
Jennie HuiBusselton Population Medical Research Institute Inc., Perth, WA, Australia.
John BeilbyBusselton Population Medical Research Institute Inc., Perth, WA, Australia.
Marie-Pierre DubéUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Centre, Montreal Heart Institute, Montreal, QC, Canada.
Gerald F WattsSchool of Medicine, The University of Western Australia, Crawley, WA, Australia.
Sonia ShahInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-5860-4526
Naomi R WrayInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-7421-3357
Wei Ling Florence LimSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID 0000-0002-8988-2147
Pratishtha ChatterjeeSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID 0000-0003-4877-1958
Ian MartinsSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID 0000-0002-2390-1501
Simon M LawsCentre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.ORCID 0000-0002-4355-7082
Tenielle PorterCentre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.
Michael VacherCentre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.
Ashley I BushThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0001-8259-9069
Christopher C RoweThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
David AmesNational Ageing Research Institute, Parkville, VIC, Australia.
Colin L MastersThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Kevin TaddeiSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Matthias ArnoldDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.ORCID 0000-0002-4666-0923
Gabi KastenmüllerInstitute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-2368-7322
Kwangsik NhoDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-1376-8532
Xianlin HanBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-8615-2413
Rima Kaddurah-DaoukDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.ORCID 0000-0003-1858-5732
Ralph N MartinsSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
John BlangeroSouth Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, USA.ORCID 0000-0001-6250-5723
Peter J MeikleBaker Heart and Diabetes Institute, Melbourne, VIC, Australia. peter.meikle@baker.edu.au.ORCID 0000-0002-2593-4665
Eric K MosesMenzies Research Institute, University of Tasmania, Hobart, TAS, Australia. eric.moses@utas.edu.au.ORCID 0000-0001-7781-4465
Baker Heart and Diabetes Institute · AUEdith Cowan University · AUThe University of Melbourne · AUThe University of Western Australia · AUDuke University · USIndiana University School of MedicinePathwest Laboratory Medicine · AUThe University of Queensland · AUUniversity of Tasmania · AUHelmholtz Zentrum München · DEMontreal Heart Institute · CAThe University of Texas Health Science Center at San Antonio · USThe University of Texas Rio Grande Valley · USUNSW Sydney · AU
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MProject 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MMetabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0MOLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINER01CA129769 · NCI · GEORGETOWN UNIVERSITY · PI AHLES, TIM ALAN, MANDELBLATT, JEANNE · 2009 to 2020
$7.3MMemory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9MMetabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type DementiasRF1AG051550 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KLING, MITCHEL ALLAN · 2015 to 2016
$6.3MMetabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9MMetabolic Networks and Pathways in Alzheimer's DiseaseR01AG046171 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F · 2014 to 2017
$4.4MMetabolic Network Analysis of Biochemical Trajectories in Alzheimer's DiseaseRF1AG057452 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2017 to 2017
$3.5MGut Liver Brain Biochemical Axis in Alzheimer's DiseaseRF1AG058942 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, VAN DUIJN, CORNELIA MARJA · 2018 to 2018
$3.4MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS R01 CA129769NIA NIH HHS K01 AG049050NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG046171NIA NIH HHS R01 AG061788NIA NIH HHS R03 AG054936NIA NIH HHS RF1 AG051550NIA NIH HHS RF1 AG057452NIA NIH HHS RF1 AG058942NIA NIH HHS RF1 AG059093NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG061359NIA NIH HHS U19 AG063744NIA NIH HHS U24 AG021886NLM NIH HHS R01 LM012535
Abstract
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P < 1 × 10
Indexed as
Coronary Artery DiseaseGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHomeostasisHumansLipidomicsLipidsPolymorphism, Single NucleotideLipids
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