SynthesisTranslational psychiatry2022
Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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45citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Neural systems underlying autobiographical memory dysregulations in depression: A neuroimaging meta-analysis.Psychological medicine · 2025Pooled it
- The ventral capsule and ventral striatum-Stereotactic targets for the management of treatment-resistant depression. A systematic literature review.Frontiers in psychiatry · 2023Pooled it
- Brain Activation Associated With Response to Psychotherapies for Late-Life Depression: A Task-Based fMRI Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Trial
- Vortioxetine Improves Brain Glymphatic System Function, Functional Connectivity, and Cognitive Functions in Major Depressive Disorder.Depression and anxiety · 2025Trial
- Nucleus accumbens neuron subtype translatome signatures in socially stressed females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response.Nature communications · 2026Article
- Functional and effective connectivity disruptions of the dopaminergic reward circuit in multiple sclerosis patients with depression.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.Molecular psychiatry · 2026Review
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.Translational psychiatry · 2026Article
- Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Cue-Dependent Fear Learning Drives Nucleus Accumbens Spine Plasticity.bioRxiv : the preprint server for biology · 2026Article
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Predictors of the Effectiveness of Psychedelics in Treating Depression-A Scoping Review.International journal of molecular sciences · 2026Article
- Limbic and whole-brain functional connectivity in non-substance abusers with human immunodeficiency virus (HIV).Journal of neurovirology · 2026Article
- Identification and functional characterization of plasma exosomal miR-618 as a novel biomarker in recurrent depressive disorder.Frontiers in pharmacology · 2026Article
- Article
- Connectome Gradient-Based Subtyping of Major Depressive Disorder Reveals Distinct Neurobiological and Transcriptomic Signatures.Depression and anxiety · 2026Article
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
Corrections and comments
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Authors and funding
74 authors at 20 institutions in 2 countries.
Yu-Dan DingDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Xiao ChenCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Zuo-Bing ChenDepartment of Rehabilitation Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Le LiCenter for Cognitive Science of Language, Beijing Language and Culture University, Beijing, China.
Xue-Ying LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Francisco Xavier CastellanosDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, 31 NY, USA.
Tong-Jian BaiAnhui Medical University, Hefei, Anhui, China.
Qi-Jing BoBeijing Anding Hospital, Capital Medical University, Beijing, China.
Jun CaoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhi-Kai ChangCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Guan-Mao ChenThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Ning-Xuan ChenCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Wei ChenSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0003-0903-7945
Chang ChengDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yu-Qi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xi-Long CuiDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Jia DuanDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Yi-Ru FangDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-8748-9085
Qi-Yong GongHuanxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-5912-4871
Zheng-Hua HouDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Lan HuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0001-5533-8859
Li KuangDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Feng LiBeijing Anding Hospital, Capital Medical University, Beijing, China.
Hui-Xian LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Kai-Ming LiHuanxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Tao LiMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yan-Song LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhe-Ning LiuDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Yi-Cheng LongDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Bin LuCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Qing-Hua LuoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hua-Qing MengDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Dai-Hui PengDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hai-Tang QiuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing, China.
Yue-Di ShenDepartment of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang, China.
Yu-Shu ShiDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Tian-Mei SiNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
Yan-Qing TangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.ORCID 0000-0003-4212-3212
Chuan-Yue WangBeijing Anding Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-6549-3713
Fei WangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Kai WangAnhui Medical University, Hefei, Anhui, China.
Li WangNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
Xiang WangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0001-9258-2017
Ying WangThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0002-0388-4177
Yu-Wei WangCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Xiao-Ping WuXi'an Central Hospital, Xi'an, Shaanxi, China.
Xin-Ran WuFaculty of Psychology, Southwest University, Chongqing, China.
Chun-Ming XieDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.
Guang-Rong XieDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Hai-Yan XieDepartment of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Peng XieInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-0081-6048
Xiu-Feng XuDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Hong YangDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jian YangChongqing Key Laboratory of Neurobiology, Chongqing, China.
Jia-Shu YaoSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Shu-Qiao YaoDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0001-6681-6844
Ying-Ying YinDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yong-Gui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yu-Feng ZangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Ai-Xia ZhangThe First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Hong ZhangXi'an Central Hospital, Xi'an, Shaanxi, China.
Ke-Rang ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID 0000-0002-4838-3384
Lei ZhangLaboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhi-Jun ZhangDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.ORCID 0000-0001-5480-0888
Jing-Ping ZhaoDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Ru-Bai ZhouDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Ting ZhouMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jun-Juan ZhuDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhi-Chen ZhuCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Chao-Jie ZouDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xi-Nian ZuoState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Chao-Gan YanCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.ORCID 0000-0003-3413-5977
Wen-Bin GuoDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. guowenbin76@csu.edu.cn.ORCID 0000-0002-1626-2465
Central South University · CNInstitute of Psychology, Chinese Academy of Sciences · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNShanghai Jiao Tong University · CNZhongda Hospital Southeast University · CNZhejiang University · CNCapital Medical University · CNChina Medical University · CNKunming Medical University · CNSichuan University · CNSouthwest University · CNAnhui Medical University · CNPeking University · CNSir Run Run Shaw Hospital · CNAffiliated Hospital of Hangzhou Normal University · CNBeijing Language and Culture University · CNBeijing Normal University · CNChildren's Hospital of Chongqing Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsistent results have been reported by studies on reward network-focused resting-state functional MRI (rs-fMRI). In this study, we examined functional alterations of the NAc-based reward circuits in patients with MDD via meta- and mega-analysis. First, we performed a coordinated-based meta-analysis with a new SDM-PSI method for all up-to-date rs-fMRI studies that focused on the reward circuits of patients with MDD. Then, we tested the meta-analysis results in the REST-meta-MDD database which provided anonymous rs-fMRI data from 186 recurrent MDDs and 465 healthy controls. Decreased functional connectivity (FC) within the reward system in patients with recurrent MDD was the most robust finding in this study. We also found disrupted NAc FCs in the DMN in patients with recurrent MDD compared with healthy controls. Specifically, the combination of disrupted NAc FCs within the reward network could discriminate patients with recurrent MDD from healthy controls with an optimal accuracy of 74.7%. This study confirmed the critical role of decreased FC in the reward network in the neuropathology of MDD. Disrupted inter-network connectivity between the reward network and DMN may also have contributed to the neural mechanisms of MDD. These abnormalities have potential to serve as brain-based biomarkers for individual diagnosis to differentiate patients with recurrent MDD from healthy controls.
Indexed as
Major Depressive DisorderBrainBrain MappingDefault Mode NetworkHumansMagnetic Resonance ImagingNeural PathwaysNucleus AccumbensReward
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