Evidence map›Paper›PMID 35668080›Full record

ReviewBone research2022

Mechanisms of bone pain: Progress in research from bench to bedside.

Gehua Zhen, Yuhan Fu, Chi Zhang, Neil C Ford, Xiaojun Wu, Qichao Wu, Dong Yan, Xueming Chen, Xu Cao, Yun Guan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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  17. Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gehua ZhenDepartment of Orthopedics, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0001-7652-6226
Yuhan FuDepartment of Orthopedics, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.
Chi ZhangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.
Neil C FordDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0003-3505-5151
Xiaojun WuDivision of Pathology, Sibley Memorial Hospital Washington, Washington, DC, 20016, USA.
Qichao WuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.
Dong YanDepartment of Oncology, Beijing Luhe Hospital, Capital Medical University, Beijing, 100149, China.
Xueming ChenDepartment of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, 100149, China.
Xu CaoDepartment of Orthopedics, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA. xcao11@jhmi.edu.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA. yguan1@jhmi.edu.ORCID http://orcid.org/0000-0003-1321-6655
Johns Hopkins University · USBeijing Luhe Hospital Affiliated to Capital Medical University · CNSibley Memorial Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with various bone diseases will aid in the appropriate application and development of optimal strategies for not only managing bone pain symptoms but also improving bone repairing and remodeling, which potentially cures the underlying etiology for long-term functional recovery. In this review, we focus on advances in important preclinical studies of significant bone pain conditions in the past 5 years that indicated new peripheral neuronal and non-neuronal mechanisms, novel targets for potential clinical interventions, and future directions of research.

Identifiers

PMID35668080
PMCPMC9170780
OpenAlexW4281887241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.