Evidence map›Paper›PMID 35667894›Full record

ArticleComputers in biology and medicine2022

Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds.

Pukar Khanal, Vishal S Patil, Vishwambhar V Bhandare, Prarambh S R Dwivedi, C S Shastry, B M Patil, Shailendra S Gurav, Darasaguppe R Harish, Subarna Roy

Open access · greenAbstract read
In one paragraph

Article in Computers in biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  17. Anti-Cholera toxin activity of selected polyphenols fromFrontiers in cellular and infection microbiology · 2023
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  19. Systems andFrontiers in pharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Pukar KhanalDepartment of Pharmacology, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore, 575018, India. Electronic address: pukarkhanal58@gmail.com.
Vishal S PatilICMR-National Institute of Traditional Medicine, Belagavi, Karnataka, 590010, India.
Vishwambhar V BhandareICMR-National Institute of Traditional Medicine, Belagavi, Karnataka, 590010, India.
Prarambh S R DwivediDepartment of Pharmacology, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore, 575018, India.
C S ShastryDepartment of Pharmacology, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore, 575018, India.
B M PatilPRES's Pravara Rural College of Pharmacy Pravaranagar, Loni, 413736, Maharashtra, India.
Shailendra S GuravDepartment of Pharmacognosy and Phytochemistry, Goa College of Pharmacy, Panaji, Goa, India.
Darasaguppe R HarishICMR-National Institute of Traditional Medicine, Belagavi, Karnataka, 590010, India. Electronic address: drharish49@gmail.com.
Subarna RoyICMR-National Institute of Traditional Medicine, Belagavi, Karnataka, 590010, India.
Nitte University · INGoa Medical College · INICMR-National Institute of Virology · INPravara Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzalacetophenones, precursors of flavonoids are aromatic ketones and enones and possess the immunostimulant as well as antiviral activities. Thus, benzalacetophenones were screened against the COVID-19 that could be lethal in patients with compromised immunity. We considered ChEBI recorded benzalacetophenone derivative(s) and evaluated their activity against 3C-like protease (3CL

Indexed as

ChalconeCOVID-19 Drug TreatmentAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesHumansMolecular Docking SimulationMolecular Dynamics SimulationProtease InhibitorsSARS-CoV-2Spike Glycoprotein, CoronavirusAntiviral AgentsChalconeCoronavirus 3C ProteasesCysteine EndopeptidasesProtease InhibitorsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-23CL(pro)BenzalacetophenonesCOVID-19Immune boostNetwork pharmacologyPL(pro)Spike protein

Identifiers

PMID35667894
PMCPMC9135652
OpenAlexW4281926870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.